ArticleJournal of conservative dentistry and endodontics2025
Antimicrobial efficacy of mangosteen, chitosan, and their combination as intracanal medicaments against
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Gram-positive oral bacteria as reservoirs of transferable antimicrobial resistance genes in dentistry.Journal of conservative dentistry and endodontics · 2026Article
- Comparative evaluation of chitosan nanoparticles and ethylenediaminetetraacetic acid as intracanal irrigants and their effect on postoperative pain reduction in single-sitting root canal treatment - A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Antimicrobial efficacy of chitosan nanoparticles as intracanal medicament againstJournal of conservative dentistry and endodontics · 2026Article
- Chihuahuan Propolis as a Non-Antibiotic Intracanal Agent AgainstMicroorganisms · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Context: The increasing prevalence of antibiotic resistance and concerns regarding adverse drug reactions have prompted interest in natural alternatives for antimicrobial treatments, particularly in endodontics. Aims: This study aimed to evaluate the antimicrobial effectiveness of mangosteen, chitosan, and their combination as intracanal medicaments against Settings and Design: A double-blind, randomized clinical trial was conducted involving 40 patients with single-rooted nonvital teeth ( Subjects and Methods: Following standard intracanal procedures, medicaments were applied, and bacterial samples were collected at baseline and after treatment. Colony-forming units (CFU) were assessed to measure the bacterial load. Statistical Analysis Used: Data were analyzed using the one-way analysis of variance ( Results: All groups showed significant CFU reduction. The Mangosteen with Chitosan group demonstrated the highest reduction (84.57%), followed by Chitosan (79.99%), Mangosteen (77.06%), and Ca(OH) Conclusions: The combination of mangosteen and chitosan showed the most effective antimicrobial activity, suggesting its potential as a natural and effective intracanal medicament.
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Registered trials
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