ArticleResearch and practice in thrombosis and haemostasis2025
Calcium binding by γ-carboxyglutamic acid: it takes two to tether.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The small family of vitamin K-dependent proteins are characterized by posttranslational modification of specific glutamic acid residues to yield γ-carboxyglutamic acid (Gla). Gla residues give these proteins calcium ion-binding properties, which are essential for a number of coagulation factors and mineralization processes. Biophysical characteristics of Gla are, however, incomplete, hindering molecular dynamics simulations and protein structure predictions. Objectives: This study aimed to elucidate the general biophysical characteristics (p Methods: Residue-based p Results: Carboxylic acid groups present on Gla residues have 2 different p Conclusion: Vitamin K-dependent proteins present Gla residues in a different manner but benefit from cooperative calcium ion binding. Experimentally determined p
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