SynthesisFrontiers in aging neuroscience2025
Orthostatic hypotension in Parkinson's disease: effects on clinical features and disease severity-a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association between cerebrospinal fluid LRRK2 and incident orthostatic hypotension differs by genetic background in Parkinson's disease.Acta neurologica Belgica · 2026Article
- Putative sympathetic-predominant subtype in body-first Parkinson's disease is associated with accelerated cognitive decline.Frontiers in aging neuroscience · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Parkinson's disease (PD) is often associated with orthostatic hypotension (OH). However, research examining the relationship between OH and PD has yielded inconsistent results. This study conducts a meta-analysis to determine the associations between OH and clinical characteristics in individuals with PD. Methods: A systematic review and meta-analysis were performed by searching for studies related to PD and OH in the PubMed, Web of Science, Embase, and Cochrane databases. Data were pooled as necessary to calculate the odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CI) for OH in PD patients. Heterogeneity was assessed using the I Results: A total of 26 articles involving 3,992 patients with Parkinson's disease were included in our study. Patients with PD and OH were significantly older at the time of examination compared to those without OH (WMD 2.94 years, 95% CI 1.91-3.97 years; I Conclusion: Patients with PD and OH tend to be older at the time of examination, exhibit a longer disease duration, and demonstrate more severe disease manifestations along with greater cognitive impairment compared to PD patients without OH. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251025263.
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