Evidence map›Paper›PMID 40746354›Full record

ArticleFrontiers in pediatrics2025

Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates.

Marie Amalie Balamurugan, Balamurugan Ramatchandirin, Suneetha Desiraju, Arjun Subrramanya, Juanitaa George Raj, Megan M Ferris, Zainab D Lawal, Oluwabunmi O Olaloye, Liza Konnikova, Krishnan MohanKumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marie Amalie BalamuruganDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Balamurugan RamatchandirinDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Suneetha DesirajuDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Arjun SubrramanyaDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Juanitaa George RajDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Megan M FerrisDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Zainab D LawalDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.
Oluwabunmi O OlaloyeDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Liza KonnikovaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Krishnan MohanKumarDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.

Funding

Function of T cells at the Maternal-Fetal InterfaceR01AI171980 · NIAID · YALE UNIVERSITY · PI Liza Konnikova · 2022 to 2026
$3.5M
Liver-Gut Axis in Neonatal Anemia and Its Role in RBC Transfusion Associated Gut InjuryR01HL163043 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Mohan Kumar Krishnan · 2023 to 2026
$1.9M
Effect of Platelet Transfusions on Neonatal Intestinal InjuryR01HL133022 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2017 to 2020
$1.6M
RBC transfusion exacerbates brain inflammation in anemic murine neonates and causes long term neurodevelopment impairmentR01HD116950 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI Mohan Kumar Krishnan · 2025 to 2026
$876k
Peripheral Immune Development in Premature Infants with and without NECR21HD102565 · NICHD · YALE UNIVERSITY · PI KONNIKOVA, LIZA, TSENG, GEORGE C. · 2020 to 2021
$456k
RBC TRANSFUSION IN ANEMIC NEONATES LEADS TO SYSTEMIC INFLAMMATORY RESPONSE SYNDROMER21HD105880 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KRISHNAN, MOHAN KUMAR · 2021 to 2022
$433k
NHLBI NIH HHS R01 HL133022NHLBI NIH HHS R01 HL163043NIAID NIH HHS R01 AI171980NICHD NIH HHS R01 HD116950NICHD NIH HHS R21 HD102565NICHD NIH HHS R21 HD105880
6 · The paper itself

Abstract

Introduction: Necrotizing Enterocolitis (NEC) is the most impactful gastrointestinal disease of premature neonates and preclinical evidence shows that the event of platelet activation is an important pathophysiological contributor during NEC-like injury in murine neonates. Integrin αIIb/β3 (glycoprotein [GP]IIb/IIIa) is the primary platelet activation marker showing increased platelet-monocytes aggregation during NEC-like injury. The present study investigates whether platelet lineage-specific deletion of integrin-β3 reduces NEC-like injury in murine neonates. Methods: C57BL/6 and integrin-β3 Results: Integrin-β3-associated platelet-monocyte aggregation was significantly observed in the intestine and blood of murine NEC-like injury and in the human NEC intestine. Platelet-specific deletion of integrin-β3's exon-1 leads to inhibition of platelet-monocyte aggregation in circulating blood and intestine, thus reducing the resulting intestinal injury and the level of inflammatory activation cytokines in the blood. Conclusion: Monocyte-platelet aggregation is an important pathophysiological event and the blockade of integrin-β3 merits a potential therapeutic target in NEC.

Indexed as

integrin beta-3monocytenecrotizing enterocolitisplateletplatelet-monocyte aggregation

Identifiers

PMID40746354
PMCPMC12310614

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.