Evidence map›Paper›PMID 40746339›Full record

ReviewDementia and neurocognitive disorders2025

Standardized Procedures for Blood and Cerebrospinal Fluid Collection and Storage in Neurodegenerative Biomarker Research: A Comprehensive Review.

Hyuk Sung Kwon, Geon Ha Kim, Sun Ah Park, So Young Moon, Jae-Won Jang, Kee Hyung Park, Young Ho Park, Jae-Sung Lim, Dong Won Yang, Seong Hye Choi and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dementia and neurocognitive disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hyuk Sung KwonDepartment of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.ORCID https://orcid.org/0000-0002-2005-0983
Geon Ha KimDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5395-1924
Sun Ah ParkLab for Neurodegenerative Dementia, Department of Anatomy, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-3027-3259
So Young MoonDepartment of Neurology, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-1025-1968
Jae-Won JangDepartment of Neurology, Kangwon National University Hospital, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-3540-530X
Kee Hyung ParkDepartment of Neurology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-6847-6679
Young Ho ParkDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.ORCID https://orcid.org/0000-0002-2756-1786
Jae-Sung LimDepartment of Neurology, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-6157-2908
Dong Won YangDepartment of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-4733-7298
Seong Hye ChoiDepartment of Neurology, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-4180-8626
Byeong C KimDepartment of Neurology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.ORCID https://orcid.org/0000-0001-6827-6730
SangYun KimDepartment of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.ORCID https://orcid.org/0000-0002-9101-5704
Seong-Ho KohDepartment of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.ORCID https://orcid.org/0000-0001-5419-5761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood and cerebrospinal fluid (CSF) biomarkers are essential tools for the rapid diagnosis and monitoring of neurodegenerative diseases like Alzheimer's disease (AD). However, even minor variations in sample collection and storage procedures can significantly impact biomarker measurements, emphasizing the importance of standardized operating procedures. This review discusses the main pre-analytical factors that influence biomarker stability, outlines the best practices for blood and CSF collection and storage, and extensively analyzes recent research findings to ensure optimal reproducibility in biomarker studies. It also discusses the future directions and recommendations for enhancing biomarker research methodologies, including advancements in automated processing and quality control measures.

Indexed as

BiomarkerBloodCerebrospinal FluidPre-Analytical Phase

Identifiers

PMID40746339
PMCPMC12310336

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.