ArticleRapid communications in mass spectrometry : RCM2025
Assessing the Quantitative Performance of Atmospheric Solids Analysis Probe-Mass Spectrometry.
Article in Rapid communications in mass spectrometry : RCM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Rapid Analysis of Sports Prohibited Substances in Black Market Pharmaceutical Products Using Atmospheric Solids Analysis Probe-Mass Spectrometry.Analytical science advances · 2026Article
- Assessing the Quantitative Performance of Atmospheric Solids Analysis Probe-Mass Spectrometry.Rapid communications in mass spectrometry : RCM · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationaleAtmospheric solids analysis probe-mass spectrometry (ASAP-MS) is an established ambient ionisation technique that allows for the direct and rapid analysis of samples without chromatographic separation. Consequently, applications that typically benefit from ambient ionisation approaches can achieve improved sample throughput and thus improved potential for in situ testing. Previous reports have contrasted in viewpoints on the ability for ASAP-MS to provide reliable quantitative data. Critically, in-depth data exploring the quantitative capabilities of ASAP-MS are currently lacking.
methodsHere, a series of experiments were performed to assess the quantitative performance of ASAP-MS using a proof-of-concept single analyte (caffeine) approach. Analytical precision, accuracy, linearity and sensitivity were investigated using numerous variables, including sample deposition method (i.e., directly placing the probe into the sample vs. pipetting the sample onto the probe) and deposition volume, as well as the presence of a series of different internal standard approaches.
resultsThe data acquired demonstrated that the use of a positive displacement pipette and an isotopically labelled (structure-matched) internal standard provided an optimal approach for quantitative reliability, albeit at levels often below the standards set for traditional chromatography-based quantitative assays. The investigations were performed across a concentration range of 50-5000 ng/mL. Whereas measurable responses were seen across the full range in most approaches, limitations in sensitivity were identified and reduced quantitative performance statistics were noted at concentrations below 1000 ng/mL.
conclusionsThese experiments demonstrate, for the first time, a comprehensive investigation into the quantitative performance of ASAP-MS using caffeine as the example analyte. These data offer insight into the current strengths and limitations of quantitative analyses using ASAP-MS and aim to provide practical recommendations to optimise quantitative approaches using this technique.
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Registered trials
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