Evidence map›Paper›PMID 40746113›Full record

ArticleInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2025

Validation of the Ultimate Stroke Scale (USS): A standardized tool for automated large vessel occlusion screening.

Sachin A Kothari, Rami Z Morsi, Elena Badillo Goicoechea, Harsh Desai, Archit Baskaran, Ahmad Chahine, Matthew Smith, Ahmad Sweid, Olivia A Kozel, Sonam Thind and 7 more

Abstract read
In one paragraph

Article in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effect of Anesthesia on Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Thrombectomy with the RECO Device.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sachin A KothariDepartment of Neurology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7740-6194
Rami Z MorsiDepartment of Neurology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-2131-3711
Elena Badillo GoicoecheaDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Harsh DesaiDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Archit BaskaranDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Ahmad ChahineDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Matthew SmithDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Ahmad SweidDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Olivia A KozelDepartment of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Sonam ThindDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Scott J MendelsonDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Rachel MehendaleDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Elisheva R ColemanDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Ali MansourDepartment of Neurology, University of Chicago, Chicago, IL, USA.
James E SieglerDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Shyam PrabhakaranDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Tareq Kass-HoutDepartment of Neurology, University of Chicago, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundPrehospital stroke screening for large vessel occlusions (LVOs) varies across institutions. This study compares manual stroke scale calculations against e-calculated scores using the Ultimate Stroke Scale (USS), a software automating multiple screening scales from a modified National Institutes of Health Stroke Scale (NIHSS) with a hand grip. The USS aims to streamline screening by computing multiple validated stroke scales simultaneously to enhance predictive value.MethodsWe applied eight stroke screening scales (NIHSS; Balance, Eyes, Face, Arms, Speech, and Time [BE-FAST]; Vision, Aphasia, Neglect; Los Angeles Motor Scale [LAMS]; Face, Arm, Speech, Time, Eye Deviation and Denial/Neglect [FAST-ED]; Emergency Medical Services Rapid Arterial oCclusion Evaluation [EMS RACE]; 3-Item Stroke Scale [3-ISS]; and Prehospital Acute Stroke Severity [PASS]) to 199 stroke activations between January 2021 and December 2023. In this prospective, external validation study, data were utilized from a previously published head-to-head comparison of multiple LVO scales for both LVOs and medium vessel occlusions which collected scales manually. We recalculated these scales using the USS and evaluated agreement (Kendall's τ) and diagnostic accuracy (ROC curves).ResultsThe USS showed strong to moderate agreement with manual calculations across all scales displayed by Kendall's τ correlation coefficients ranging from 0.549 to 0.931 (all

Indexed as

large-vessel occlusionscreeningsensitivityspecificityStrokesystems

Identifiers

PMID40746113
PMCPMC12316682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.