Evidence map›Paper›PMID 40746035›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Zinc-Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post-Pancreatectomy Cutaneous Wound Healing.

Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yedong MaDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.ORCID 0000-0002-1439-5045
Chengke XieDepartment of Hepatobiliary Pancreatic Surgery, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, 350001, China.
Chengyu LiaoDepartment of Hepatobiliary Pancreatic Surgery, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, 350001, China.
Binting HuangDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
Siqi LiuDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
Junhua KongInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A∗STAR), Innovis, 2 Fusionopolis Way, Singapore, 138634, Singapore.
Xiaotong FanInstitute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore.ORCID 0009-0001-2574-5776
Zibiao LiDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.
Shi ChenDepartment of Hepatobiliary Pancreatic Surgery, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, 350001, China.
Chaobin HeDepartment of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore.ORCID 0000-0001-8200-8337

Funding

Fujian Province Science and Technology Innovation Joint Fund Project 2023Y9334Fujian Province Science and Technology Innovation Joint Fund Project 2024Y9070Fujian Research and Training Grants for Young and Middle-aged Leaders in Healthcare 2021(60)Ministry of Education - Singapore MOE-T2EP50223-0004National Natural Science Foundation of China 82473009Provincial Hospital Affiliated with Fuzhou University National Natural Science Foundation Talent Cultivation Program 00802732
6 · The paper itself

Abstract

Orchestration of enzyme cascades in synthetic systems remains a major challenge for catalytic control in complex biological environments. Here, a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) is reported that mimics natural enzymatic assemblies by confining individual glucose oxidase (GOX), superoxide dismutase (SOD), and catalase (CAT) within an imidazole-functionalized polymeric nanogel matrix. The nanogel is fabricated via mild in situ polymerization combined with Zn

Indexed as

Polyethylene GlycolsPolyethyleneimineWound HealingZincAnimalsAnti-Bacterial AgentsCatalaseGlucose OxidaseImidazolesMiceNanogelsSkinSuperoxide DismutaseAnti-Bacterial AgentsCatalaseGlucose OxidaseImidazolesNanogelsPolyethylene GlycolsPolyethyleneimineSuperoxide DismutaseZinccoordinationenzyme cascadesnanogelspancreatectomywound healing

Identifiers

PMID40746035
PMCPMC12710564

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.