Evidence map›Paper›PMID 40746030›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2025

Improving Muscle Function Through a Multimodal Behavioural Intervention for Knee Osteoarthritis and Obesity: The POMELO Trial.

Kristine Godziuk, Mary Forhan, Flavio T Vieira, Joao F Mota, Jason Werle, John A Batsis, Lorenzo M Donini, Mario Siervo, Carla M Prado

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05026385 (Targeted Knee Osteoarthritis Care for Adults With a BMI ≥35 kg/m2), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05026385 nacompletednot on this map

Targeted Knee Osteoarthritis Care for Adults With a BMI ≥35 kg/m2: the Prevention Of MusclE Loss in Osteoarthritis (P.O.M.E.L.O.) Feasibility and Pilot Randomized Trial

TypeinterventionalSponsorUniversity of AlbertaRan2021 to 2023Enrolled50ConditionsOsteoarthritis, Knee, ObesityArmsIntervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Osteoarthritis as a systemic disease.Nature reviews. Rheumatology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristine GodziukDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada.ORCID 0000-0001-9520-4302
Mary ForhanDepartment of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Flavio T VieiraDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada.
Joao F MotaFaculty of Nutrition, Federal University of Goias, Goiânia, Brazil.
Jason WerleSection of Orthopaedic Surgery, Department of Surgery, University of Calgary, Calgary, Canada.
John A BatsisDivision of Geriatric Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Lorenzo M DoniniExperimental Medicine Department, Sapienza University, Rome, Italy.
Mario SiervoSchool of Population Health, Curtin University, Perth, Australia.
Carla M PradoDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada.

Funding

Alberta Innovates and Obesity Canada Postdoctoral FellowshipsAlberta Innovates and Women and Children's Health Research Institute Postdoctoral FellowshipsArthritis Society Canada SOG-20-00033Campus Alberta Innovation Program Chair and the Canada Research Chairs ProgramCanadian Foundation for Innovation 34115
6 · The paper itself

Abstract

backgroundTreatments aimed at improving physical function and body composition, including reducing fat mass (FM) and increasing muscle mass, may benefit individuals with advanced knee osteoarthritis (OA) and obesity. We investigated the feasibility and efficacy of a multimodal behavioural intervention compared to usual care to enhance physical function and muscle mass in this population.

methodsThe POMELO (Prevention Of MusclE Loss in Osteoarthritis) study is a two-arm pilot randomized controlled trial; NCT05026385. Participants aged 40-75 years, with a BMI ≥ 35 kg/m

resultsFifty participants were randomized (POMELO = 25, UC = 25), with 32 completing the study (69% female, mean age 64.9 ± 1.2 years, BMI 42.1 ± 1.0 kg/m

conclusionThe POMELO intervention, combining personalized nutrition, resistance exercise and self-management support, was feasible, acceptable and showed greater efficacy than usual care to improve physical function in patients with knee OA and obesity. Our pilot study of this intervention showed potential benefits on body composition and quality of life without focusing on weight reduction. A larger study is needed to confirm these results, as this approach may offer advantages over usual care, potentially leading to better mobility and health outcomes.

Indexed as

Behavior TherapyObesityOsteoarthritis, KneeAdultAgedBody CompositionCombined Modality TherapyFemaleHumansMaleMiddle AgedPilot ProjectsQuality of LifeTreatment Outcomebody compositionexerciseinterventionknee osteoarthritismultimodal interventionnutrition interventionobesityphysical functionsarcopenic obesity

Identifiers

PMID40746030
PMCPMC12314308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.