ArticleSmall (Weinheim an der Bergstrasse, Germany)2025
Modeling Adipokine and Insulin-Mediated Crosstalk Between Adipocytes and Beta Cells Using Flow-Enabled Microfluidics.
Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Review
- Association of high-density lipoprotein-related inflammatory indicators with diabetic foot ulcer in patients with diabetes: a population-based study.Diabetology & metabolic syndrome · 2025Article
- Modeling Adipokine and Insulin-Mediated Crosstalk Between Adipocytes and Beta Cells Using Flow-Enabled Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Obesity-associated beta cell dysfunction is a crucial factor in the pathogenesis of Type 2 Diabetes (T2D), driven by a dysfunctional crosstalk between adipose tissues and pancreatic beta cells. Traditional culture systems cannot capture this crosstalk in a dynamic and controlled manner. A flow-enabled microfluidic is developed with an embedded micro-Tesla (µTesla) pump to assess the adipocyte-beta cell crosstalk. This recirculating system allows them to study the transport of soluble-factor-based between cultured 3T3 L1 adipocytes and INS1 beta cells. It is found that flow-enabled incubation with elevated glucose and insulin increased the levels of adipocyte-derived secretions of IL-6, TNF-α, and adiponectin in the media. In turn, adipocyte-derived IL-6 enhanced beta-cell insulin secretions in the same media, establishing a feed-forward loop. This mechanism can contribute to the hyperinsulinemia and pro-inflammatory conditions characteristic of obesity-related T2D. The findings highlight the advantages of flow-enabled microfluidics in modeling adipocyte-beta cell crosstalk in obesity, providing novel insights into obesity-associated beta cell dysfunction.
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