ArticleAngewandte Chemie (International ed. in English)2025
Smiles-Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Photoredox-Neutral Platform for Direct Decarboxylative CyclopropanationACS catalysis · 2026Article
- Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom-Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres.Angewandte Chemie (International ed. in English) · 2026Article
- Smiles-Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis.Angewandte Chemie (International ed. in English) · 2025Article
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3 authors.
Funding
Abstract
We describe a triple C─C bond cascade process for heteroaryl cyclopropane synthesis, through the reaction of vinyl sulfonium salts and sulfones under mild conditions. An initial conjugate addition (C─C bond 1) sets up a Smiles-Truce rearrangement (C─C bond 2), with a final 3-exo-tet ring closure (C─C bond 3) affording cyclopropanes. Serendipitously, we uncovered a novel reaction variant that affords sultines, an under-explored heterocycle with potential application as a bioisostere in medicinal chemistry.
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