ArticleNucleus (Austin, Tex.)2025
Oncogenic lncRNA transgene transcription modulates epigenetic memory at a naïve chromosomal locus.
Article in Nucleus (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- MetaChrome: an open-source, user-friendly tool for automated metaphase chromosome analysis.Methods (San Diego, Calif.) · 2026Article
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4 authors.
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Abstract
Maintaining genome integrity is essential for the proper functioning and development of organisms. An intriguing aspect is that neocentromeres can form at non-centromeric sites. CENP-A, a key epigenetic marker of centromeres, is often mislocalized to ectopic sites in cancers when overexpressed. Its deposition on centromeres relies on transcription of centromeric non-coding RNAs. Subsequently, ectopic CENP-A is frequently found at transcriptionally active and chromosome breakpoint regions. We previously engineered a stable ectopic CENP-A site on a naïve chromosome by overexpressing PCAT2, a non-centromeric oncogenic lncRNA that recruits CENP-A to its transcribing locus. We tracked cells with this transgene to analyze the longevity of ectopic CENP-A. We discovered that this induced epigenetic memory was lost due to suppression by epigenetic silencing mechanisms, restoring CENP-A to previous levels. These findings suggest that cells have mechanisms to prevent neocentromere formation at ectopic sites by suppressing transcription unless selective pressure favors it.
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