Evidence map›Paper›PMID 40745695›Full record

GuidelineVeterinary dermatology2025

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis.

Manolis N Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas-Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli

Abstract readPractice Guideline
In one paragraph

Guideline in Veterinary dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Pathogens (Basel, Switzerland) · 2026
    Article
  12. Autochthonous canine cutaneous leishmaniasis caused byCurrent research in parasitology & vector-borne diseases · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. StandardizedVeterinary sciences · 2025
    Article
  17. Emergence of autochthonousFrontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Manolis N SaridomichelakisClinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece.ORCID https://orcid.org/0000-0001-8308-3371
Gad BanethKoret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.ORCID https://orcid.org/0000-0002-7549-1305
Silvia ColomboStudio Dermatologico Veterinario, Milano, Italy.ORCID https://orcid.org/0000-0003-1138-4364
Filipe Dantas-TorresAggeu Magalhães Institute, Fundação Oswaldo Cruz (Fiocruz), Recife, Brazil.ORCID https://orcid.org/0000-0002-1496-6274
Lluís FerrerDepartament de Medicina i Cirurgia Animals, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID https://orcid.org/0000-0003-1537-0074
Alessandra FondatiVeterinaria Cetego, Roma, Italy.ORCID https://orcid.org/0009-0002-2202-214X
Guadalupe MiróDepartment of Animal Health, Veterinary Teaching Hospital, Faculty of Veterinary, Universidad Complutense de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0003-0981-2470
Laura OrdeixDepartament de Medicina i Cirurgia Animals, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID https://orcid.org/0000-0002-3631-8358
Domenico OtrantoDepartment of Veterinary Medicine, University of Bari, Bari, Italy.ORCID https://orcid.org/0000-0002-7518-476X
Chiara NoliServizi Dermatologici Veterinari, Peveragno, Cuneo, Italy.ORCID https://orcid.org/0000-0002-2310-9813

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCanine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention.

objectivesTo provide consensus guidelines for diagnosis and evidence-based guidelines for treatment and prevention of CanL. METHODS AND MATERIAL: Clinical consensus guidelines for the diagnosis were structured based on literature and authors' experience. Three electronic databases were searched for randomised controlled trials, systematic reviews and meta-analyses on treatment and prevention. RESULTS, CONCLUSIONS AND CLINICAL IMPORTANCE: Diagnosis should be based on compatible clinical signs and/or clinicopathologic abnormalities, exclusion of differentials, demonstration of infection and increased concentration of anti-Leishmania IgG (quantitative serology). Euthanasia for public health purposes is not recommended and drugs with anti-Leishmania activity should be avoided in subclinically infected dogs. Recommended treatments include meglumine antimoniate-allopurinol (first-line treatment), miltefosine-allopurinol (first-line treatment) and aminosidine-allopurinol (second-line treatment); marbofloxacin may be considered in dogs with advanced chronic kidney disease. In endemic areas, recommended measures for prevention include deltamethrin 4% collar, flumethrin 4.5%-imidacloprid 10% collar or permethrin 50%-imidacloprid 10% spot-on, not using infected blood products for transfusion, not breeding seropositive bitches or dogs with CanL, administration of domperidone (seronegative dogs) and dietary nucleotides-active hexose correlated compound (subclinically infected, seropositive dogs). Vaccination with LiESP with MDP may be considered, whereas protein Q vaccine is recommended in areas with very high rates of seroconversion. In non-endemic areas, recommended measures include not using infected blood products for transfusion and removal of infected female dogs from reproduction.

Indexed as

Dog DiseasesLeishmaniasisLeishmaniasis, VisceralAnimalsAntiprotozoal AgentsDogsLeishmania infantumSystematic Reviews as TopicAntiprotozoal Agentsallopurinolaminosidinedeltamethrindomperidoneflumethrinmeglumine antimoniatemiltefosinenutritional supplementpermethrinvaccine

Identifiers

PMID40745695
PMCPMC12590123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.