ArticleJournal of cellular and molecular medicine2025
The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Ultrasound-activated trilayer piezoelectric bio-adhesive for rapid repair and antibacterial treatment of gastrointestinal perforation.Bioactive materials · 2026Article
- Piezo1-mediated Mechanotransduction in the musculoskeletal system: Signaling networks and therapeutic perspectives.Bone reports · 2026Review
- Review
- [Research progress on clinical transformation of Piezo1 in osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
- Research progress on cellular senescence in the pathogenesis and treatment of osteoarthritis and temporomandibular joint osteoarthritis.Journal of oral & facial pain and headache · 2026Review
- Signaling pathways and ion channels in osteoarthritis: a review of recent advances.Frontiers in immunology · 2026Review
- Piezo1-mediated mechanotransduction and metabolic regulation in bone health: molecular mechanisms and implications for bone disorders.Frontiers in cell and developmental biology · 2026Review
- The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis.Journal of cellular and molecular medicine · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Osteoarthritis (OA) is a highly prevalent chronic joint disease with complicated pathogenesis, causing pain and dysfunction. The mechanosensitive ion channel Piezo1 is an important mechanoreceptor on chondrocytes and may be involved in the process of OA. However, its role and mechanism remain elusive. This study investigated the role and possible mechanisms of Piezo1 in OA induced by excessive mechanical stress. Piezo1 expression levels were markedly up-regulated in the lesioned region of the medial tibial cartilage in OA rats subjected to destabilisation of the medial meniscus (DMM) surgery. Excessive mechanical stress increases Piezo1 in chondrocytes, which leads to a reduction in collagen II (COL2) and aggrecan (ACAN). In addition, activation of Piezo1 channels by the specific agonist Yoda1 reduces chondrocyte anabolism and promotes catabolism. Molecularly, activation or inhibition of Piezo1 modulates the activity of the PI3K/AKT/mTORC1 pathway. Inhibition of the PI3K/AKT pathway or mTORC1 alleviated the Yoda1-induced imbalance of chondrocyte homeostasis to varying degrees. Collectively, these findings imply that Piezo1 in chondrocytes may respond to excessive mechanical forces and promote extracellular matrix degradation through the PI3K/AKT/mTORC1 pathway, thereby driving OA progression.
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