Trial reportBMC oral health2025
The role of probiotics and dietary interventions in the treatment of periodontitis: a pilot randomized controlled clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06944938 (The Role of Probiotics and Dietary Interventions in the Treatment of Periodontitis), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Probiotics and Dietary Interventions in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial
Who cites it
4 citing papers in PubMed.
- Nutritional Stunting Is Linked to Reduced Oral Microbiome Stability and Reconfigured Microbial Networks in Children: A Pilot Intervention Study.Pathogens (Basel, Switzerland) · 2026Trial
- Strontium-incorporated thermoresponsive hydrogel platform co-delivering graphene oxide-mannose nanocomplexes: An osteoimmunomodulatory strategy for periodontitis therapy.Materials today. Bio · 2026Article
- Adjunctive Therapies in Periodontitis: Current Concepts and the Future.Journal of periodontal research · 2026Review
- Using the Immune System for Effective Periodontal and Caries Management.BioMed research international · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this pilot study was to evaluate the effects of probiotic supplementation and diet-supported probiotic use on periodontal clinical parameters in individuals with periodontitis.
methodsA total of 120 female participants aged between 20 and 60 years, diagnosed with periodontitis and without systemic diseases, were included in the study. Participants were randomly assigned into three groups: control group (conventional treatment), probiotic group (conventional treatment + probiotics), and diet + probiotic group (conventional treatment + probiotics + personalized diet). Clinical evaluations were performed using measurements of probing depth (PD) and clinical attachment loss (CAL), while dietary intake was assessed using three-day food records. Data were analyzed using SPSS 21.0 software, and p < 0.05 was considered statistically significant.
resultsAfter a six-week follow-up, significant reductions in PD and CAL were observed in the probiotic and especially the diet-supported probiotic groups (p < 0.001). In the diet + probiotic group, PD improved by 41.5% and CAL by 42.7%. Nutritional analysis revealed that protein and fiber intake supported periodontal improvement, whereas sugar and carbohydrate consumption had negative effects (p < 0.05).
conclusionProbiotics were found to support periodontal healing, and this effect was significantly enhanced by a personalized anti-inflammatory diet. It is recommended that probiotics and balanced nutrition be integrated into a holistic approach in the treatment of periodontitis.
trial registrationClinicalTrials.gov Identifier: NCT06944938, First Submitted: 10/04/2025 (Retrospectively registered) First Posted: 25/04/2025.
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