SynthesisBMC surgery2025
Thyroidectomy versus antithyroid drugs in Graves' disease: a meta-analysis of randomized controlled trials.
Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis meta-analysis was developed to compare the clinical outcomes associated with thyroidectomy and antithyroid drug treatment in Graves' disease patients, with a focus on outcomes including ophthalmopathy onset or progress, the hyperthyroid cure rate, and the incidence of adverse events.
methodsA systematic search of the PubMed, Web of Science, Embase, National Knowledge Infrastructure, China, and SinoMed databases was performed to identify randomized controlled trials (RCTs) comparing thyroidectomy and antithyroid drugs as treatments for Graves' disease. Study quality was measured with the Cochrane risk of bias tool. Review Manager 5.4 and Stata 14.0 were employed to analyze the pooled data from these studies. The resultant data were reported as 95% confidence interval (CI) values and weighted mean differences. Fixed- or random-effects models were selected for pooled estimates based on the degree of heterogeneity among studies.
resultsFollowing a review of the literature, 7 RCTs enrolling 715 patients were incorporated into this meta-analysis. Thyroidectomy was associated with a significantly better hyperthyroid cure rate as compared to antithyroid drugs (OR 3.03, 95% CI: 1.05 to 8.97, P = 0.04), while also being associated with a lower rate of recurrence. Ophthalmopathy onset/worsening and adverse event incidence were comparable in both groups.
conclusionAs compared to antithyroid drug administration, thyroidectomy can achieve higher hyperthyroid cure rates and a lower risk of recurrence in Graves' disease patients without any concomitant rise in ophthalmopathy risk or adverse advent incidence. In cases where antithyroid drug treatment is not optimal, thyroidectomy can thus be recommended as a more promising approach to treating Graves' disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.