Evidence map›Paper›PMID 40745602›Full record

ArticleBMC geriatrics2025

Sex modifies the association between malnutrition and chronic kidney disease in community-dwelling older adults in the United States.

Rongting Zhang, Ke Zhu, Kaijun Zhang, Yinxia Zhu, Yani Wang, Ying Liao, Yong Fang, Yunli Shen

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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Rongting Zhang *Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Ke Zhu *Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Kaijun Zhang *Department of Pulmonary and Critical Care Medicine, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
Yinxia ZhuDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Yani WangDepartment of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
Ying LiaoDepartment of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
Yong FangDepartment of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
Yunli ShenDepartment of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. yunlishen5566@163.com.

Funding

Top-level Clinical Discipline Project of Shanghai Pudong District PWYgf2021-01Training plan for discipline leaders of Shanghai Pudong New Area Health Commission PWRd2020-09
6 · The paper itself

Abstract

backgroundPrevious studies focused on the relationship between nutritional status and adverse outcomes in patients with chronic kidney disease (CKD). However, the relationship between malnutrition and CKD in community-dwelling older adults in the United States is largely unknown.

methodsOverall, 8,219 participants were included in this study, and classified as normal nutritional status, mild malnutrition, and moderate to severe malnutrition by Controlling Nutritional Status (CONUT) score. The relationship between malnutrition and the risk of CKD was investigated through a multivariable logistic regression analysis.

resultsThe average age of participants in this study was 73.0 ± 5.5 years, 3,517 (40%) had CKD. A multivariate logistic regression model revealed that, compared to a normal nutritional state, malnutrition was significantly associated with an increased risk for CKD. The adjusted odds ratios (OR) for mild and moderate to severe malnutrition were 1.27 (95% confidence interval [CI]: 1.04-1.54) and 1.88 (95% CI: 1.19-2.97), respectively. However, among male participants, malnutrition did not show a relationship with the prevalence of CKD, with adjusted ORs of 1.00 (95% CI: 0.78-1.30) for mild malnutrition and 1.47 (95% CI: 0.87-2.49) for moderate to severe malnutrition. Our findings showed that there was an interaction between sex and malnutrition in relation to CKD risk (P for interaction < 0.001).

conclusionsIn elderly participants, malnutrition is significantly correlated with a higher prevalence of CKD, and sex can modify the relationship between them.

Indexed as

Independent LivingMalnutritionRenal Insufficiency, ChronicAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleNutritional StatusRisk FactorsSex FactorsUnited StatesChronic kidney diseaseControlling nutritional status scoreElderlyMalnutritionSex differences

Identifiers

PMID40745602
PMCPMC12312591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.