Observational studyBMC gastroenterology2025
Effect of plasma adsorption and low-volume plasma exchange on intracranial pressure in acute-on-chronic liver failure: a prospective observational study.
Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
backgroundPatients with liver failure may be accompanied by cerebral edema and elevated intracranial pressure (ICP). The effect of plasma adsorption (PA) and low-volume plasma exchange (PE) on ICP were unclear.
methodsA prospective observational cohort study was conducted in patients with acute-on-chronic liver failure (ACLF) receiving PA followed immediately by low-volume PE. ICP was measured by transcranial doppler (TCD) and flash visual evoked potential (FVEP). ICP, mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) were measured repeatedly, and their differences were evaluated by generalized estimation equation.
resultsA total of 31 patients with ACLF were enrolled. The median MELD 3.0 was 27.8 (25.7 ~ 29.4). Compared with ICP measured by FVEP (ICP
conclusionPA and low-volume PE treatment might have no effect on ICP in patients with ACLF, while low-volume PE rather than PA treatment could improve MAP and CPP.
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