ArticleBMC cardiovascular disorders2025
Prognostic impact of systemic immune inflammatory index in patients with reduced ejection fraction heart failure.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association of albumin-bilirubin score with clinical severity and outcome in patients with decompensated heart failure: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Research status and hotspots of the systemic immune-inflammation index: A bibliometric analysis.Medicine · 2026Article
- Prognostic Value of Systemic Inflammatory Indices in Hospitalized Patients with HFrEF: A Multicenter Retrospective Cohort Study.International journal of general medicine · 2026Article
- Development and validation of a prediction model for 1-year all-cause rehospitalisation after discharge in patients with heart failure with preserved ejection fraction based on the systemic immune-inflammation index.Frontiers in cardiovascular medicine · 2026Article
- The association between systemic immune-inflammation index and mortality of elderly chronic bronchitis patients complicated by acute myocardial infarction.Frontiers in cardiovascular medicine · 2026Article
- Natriuretic peptides testing and survival prediction models for chronic heart failure: a systematic review of added prognostic value.Diagnostic and prognostic research · 2025Review
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7 authors.
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Abstract
backgroundThe systemic immune-inflammation index (SII), a novel marker derived from the combination of platelet, neutrophil, and lymphocyte counts, has been linked to unfavorable clinical outcomes in various malignancies and inflammatory conditions. This study aims to assess the association between SII and disease prognosis in patients with heart failure with reduced ejection fraction (HFrEF).
methodsA total of 521 patients (72% male; mean age: 67 ± 13 years) diagnosed with HFrEF were retrospectively analyzed. Clinical, demographic, laboratory, and echocardiographic data were collected. SII scores were calculated for all patients, and their prognostic significance and clinical outcomes were evaluated.
results521 patients were analyzed. According to current findings, all-cause mortality occurred in 87 patient during the follow-up period. The mean SII in the mortality group was higher than in the survivors and was found to be statistically significant. (878.57 vs. 643.65; p = 0.003, respectively) In the multivariable regression model SII was found to be an independent risk factor for mortality. (p = 0.031) The AUC of SII for mortality prediction was 0.602 (95% CI = 0.531-0.673), the cut-off value was 729, and the sensitivity and specificity were 59.3% and 59.6% (p = 0.003).
conclusionThis study demonstrates a significant association between SII and both survival and prognosis in patients with HFrEF. Notably, the SII index was found to be an independent predictor of mortality in this patient population.
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