ArticleBMC anesthesiology2025
Minimum alveolar concentration of sevoflurane with a rapid intravenous administration of dexmedetomidine for deep extubation in children.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The effect of deep extubation on the emergence agitation in pediatric patients undergoing obstructive sleep apnea syndrome surgery: a randomized controlled study.Scientific reports · 2026Trial
- Dental Management of CHARGE Syndrome Under General Anaesthesia: A Case Report.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryArticle
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Authors and funding
4 authors.
Funding
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Abstract
backgroundDeep extubation has potential advantages in certain patients and surgeries. The end tidal concentration of sevoflurane, the most used inhalation anesthetic in pediatric anesthesia, is an important factor to determine whether smooth deep extubation can be achieved. Dexmedetomidine decreases the requirement of volatile anesthetics. This study was conducted to determine the 50% effective end-tidal concentration of sevoflurane (ED50) for deep tracheal extubation in combination with an intravenous injection of low dose dexmedetomidine.
methodsThirty-six children undergoing adenotonsillectomy, with ASA physical status I-II and aged 3-10 years, were enrolled in the study. At the end of surgery, 0.5 µg/kg dexmedetomidine diluted in 10 ml saline was administered. The up and down sequential study design was employed to determine the effective dose of sevoflurane for smooth deep extubation, starting at 1.0% with subsequent 0.1% up and down in the next patient based on whether smooth extubation had been achieved or not. Smooth extubation was defined as no movement, coughing, bucking, breath holding or laryngospasm within 1 min after extubation.
resultsED50 (95% CI) of the end-tidal concentration of sevoflurane required for smooth deep extubation was 0.90% (0.79-1.02%). ED95 (95% CI) values of sevoflurane was 1.70% (1.58-1.81%). No respiratory and hemodynamic complications were observed.
conclusionThe ED50 of sevoflurane for smooth deep extubation with a 0.5 µg/kg bolus of dexmedetomidine administered before extubation was 0.90% in pediatric patients undergoing adenotonsillectomy with perioperative hydromorphone (5 µg/kg).
trial registrationChiCTR2300070329, registered on 10 April 2023.
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