Evidence map›Paper›PMID 40745509›Full record

ArticlePediatric cardiology2026

Type and Frequency of Arrhythmias Status Post Hybrid Procedure at 6 Years of Age.

Garrett Muckleroy, Phillip Cheng, Isaac Kistler, Samantha Fichtner, Tamara Ackley, Omar Khalid, Mark Galantowicz, Anna Kamp, Clifford L Cua

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Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Garrett MuckleroyHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA. garrett.muckleroy@nationwidechildrens.org.
Phillip ChengHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Isaac KistlerHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Samantha FichtnerHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Tamara AckleyHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Omar KhalidHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Mark GalantowiczHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Anna KampHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Clifford L CuaHeart Center, Nationwide Children's Hospital, Columbus, OH, 43205, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hybrid pathway is an alternative surgical route for patients with hypoplastic left heart syndrome (HLHS) and patients with single-ventricle systemic obstructive physiology. Limited data exist on post-Fontan arrhythmias in these patients. This study aimed to assess the type and frequency of arrhythmias post-Fontan in hybrid pathway patients and compare them to the Single Ventricle Reconstruction Trial (SVRT). A retrospective chart review was performed on all patients with single-ventricle anatomy who underwent the hybrid procedure and subsequently completed the Fontan surgery. Exclusion criteria included incomplete pre- or post-operative Fontan data or lack of post-Fontan hospital discharge. Baseline demographics, pre-Fontan ECG, 6-year ECG and Holter, and cardiac medications were recorded. Arrhythmias were defined as isolated atrial or ventricular ectopy, non-sustained or sustained tachyarrhythmias. A total of 116 patients met criteria (HLHS n = 79, single-ventricle variants n = 37). Fontan age was 2.7 ± 0.7 years, post-Fontan ECG age was 6.4 ± 0.9 years, and Holter age was 7.0 ± 1.8 years. Mortality occurred in 3 patients and transplantation in 2 patients. Atrial arrhythmias appeared in 69% (70/102) of the Holters, mostly isolated (70/70,100%) and rare (65/70, 93%). Ventricular arrhythmias appeared in 62% (63/102), also mainly isolated (63/63, 100%), and rare (62/63, 98%). Any degree of AV block occurred in 8.8% (9/102) and pacemaker placement occurred in 2.6% (3/116). PR interval, QRS duration, and QTc values were not associated with death or transplantation. Hybrid pathway had higher odds of atrial arrhythmias compared to SVRT Norwood-shunt (OR 4.11 (2.29, 7.53)) and Norwood-conduit (OR 4.38 (2.46, 7.92)). Odds ratios were not different for ventricular arrhythmias between the three groups. Hybrid pathway had a lower odds ratio for any degree of AV block compared to the Norwood-conduit group (0.35 (0.14, 0.76)). Incidence of pacemakers was similar between hybrid (2.9%), Norwood-shunt (4.2%), and Norwood-conduit (3.8%) groups. At 6 years post-Fontan, benign atrial and ventricular arrhythmias were common in patients on the hybrid pathway. Incidence of atrial arrhythmias was higher in the hybrid group compared to the SVRT data, mostly due to isolated, rare atrial ectopy. The incidence of ventricular arrhythmia types and pacemaker placement were similar to SVRT data. Ongoing surveillance in this high-risk population is recommended.

Indexed as

Arrhythmias, CardiacFontan ProcedureHeart VentriclesHypoplastic Left Heart SyndromePostoperative ComplicationsChildChild, PreschoolElectrocardiographyElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHumansMaleRetrospective StudiesArrhythmiasCongenital heart diseaseHybrid procedureHypoplastic left heart syndrome

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.