Evidence map›Paper›PMID 40745479›Full record

ArticleNature chemical biology2026

Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context.

Ramon Hurtado-Guerrero, Spyridon Gatos, Irene Ginés-Alcober, Javier Macías-León, Andrés Manuel González-Ramírez, Ilknur Kasapoglu, Billy Veloz, Ismael Compañón, Mattia Ghirardello, Pedro Merino and 2 more

Abstract read
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In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ramon Hurtado-Guerrero *Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain. rhurtado@bifi.es.ORCID 0000-0002-3122-9401
Spyridon Gatos *Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.ORCID 0000-0002-0530-0681
Irene Ginés-Alcober *Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain.
Javier Macías-León *Institute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain.
Andrés Manuel González-RamírezInstitute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain.ORCID 0000-0002-5838-0857
Ilknur KasapogluDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.ORCID 0009-0002-8520-7061
Billy VelozInstitute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain.
Ismael CompañónDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, Spain.
Mattia GhirardelloDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, Spain.ORCID 0000-0002-2855-4801
Pedro MerinoInstitute of Biocomputation and Physics of Complex Systems, University of Zaragoza, Campus Rio Ebro, Zaragoza, Spain.
Francisco CorzanaDepartamento de Química and Instituto de Investigación en Química de la Universidad de La Rioja (IQUR), Universidad de La Rioja, Logroño, Spain.ORCID 0000-0001-5597-8127
Ola Blixt *Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark. olablixt@combotope.com.

Funding

Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) PID2021-127622OB-I00
6 · The paper itself

Abstract

Developing high-affinity monoclonal antibodies (mAbs) against tumor-associated carbohydrate antigens such as Tn and STn on carrier proteins remains a major challenge in cancer therapy. These antigens, expressed as glycan-peptide epitopes (combotopes), require precise recognition for high specificity. Through structural studies, we found that V

Indexed as

Antibodies, MonoclonalAntigens, Tumor-Associated, CarbohydratePeptide LibraryPolysaccharidesCell Line, TumorEpitopesHumansMucin-1Antibodies, MonoclonalAntigens, Tumor-Associated, CarbohydrateEpitopesMucin-1Peptide LibraryPolysaccharidesTn antigen

Identifiers

PMID40745479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.