Evidence map›Paper›PMID 40745478›Full record

ArticleNature chemical biology2025

GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant.

Priyanshi Rana, Anjana Edathil Kadangodan, Paulami Koley, Riya Ghosh, Naga Jyothi Pullagurla, Hemant Chandru Naik, Padmabati Mondal, Srimonta Gayen, Debabrata Laha

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Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsPAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Gibberellin biosynthesis inFrontiers in plant science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Priyanshi RanaDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India.
Anjana Edathil KadangodanDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India.
Paulami KoleyDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India.
Riya GhoshDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India.
Naga Jyothi PullagurlaDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India.
Hemant Chandru NaikDepartment of Developmental Biology and Genetics, IISc, Bengaluru, India.
Padmabati MondalDepartment of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati, India.
Srimonta GayenDepartment of Developmental Biology and Genetics, IISc, Bengaluru, India.
Debabrata LahaDepartment of Biochemistry, Indian Institute of Science (IISc), Bengaluru, India. dlaha@iisc.ac.in.ORCID http://orcid.org/0000-0002-7823-5489

Funding

Council of Scientific and Industrial Research (CSIR) NoneDepartment of Biotechnology, Ministry of Science and Technology (DBT) BT/PR43116/BRB/10/2010/2021University Grants Commission (University Grants Commission India) None
6 · The paper itself

Abstract

DELLA proteins integrate external and internal cues into a signaling network critical for land plant survival. In flowering plants, gibberellins (GAs) induce DELLA recognition to its receptor GID1, resulting in the polyubiquitylation and degradation of DELLA repressors. Notably, bryophytes lack the canonical GA receptor, despite the presence of genes encoding DELLA in these nonvascular land plants. Consequently, the underlying molecular mechanisms of DELLA regulation in bryophytes have remained largely elusive. Here, we report that MpVIH, responsible for the synthesis of inositol pyrophosphate messenger InsP

Indexed as

GibberellinsInositol PhosphatesMarchantiaPlant ProteinsGene Expression Regulation, PlantGibberellinsInositol PhosphatesPlant Proteins

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.