ArticleScientific reports2025
Adverse childhood experiences impair cognitive function via social isolation and functional limitations in Chinese middle-aged and older adults.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Relationship between adverse childhood experiences and motoric cognitive risk in Chinese older adults: a nationwide study.Archives of public health = Archives belges de sante publique · 2026Article
- Life-Course Psychosocial Stress and Risk of Dementia and Stroke in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Adverse childhood experiences, early menopause, cognition, and dementia in older adults in the United States.Communications health · 2026Article
- Dilemmas in the usage of community-based home care and smart home care services for older adults among family caregivers of older adults with mild cognitive impairment (MCI): a qualitative study.Frontiers in public health · 2025Article
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7 authors.
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Abstract
Adverse childhood experiences (ACEs) are among the factors affecting cognitive function in middle-aged and older adults, but the combined effects of ACEs, social isolation and functional limitations on cognitive function have not been fully explored. This study used data from 6412 middle-aged and older adults from the 2018 China Health and Retirement Longitudinal Study (CHARLS) and the 2014 CHARLS Life Histories Survey. Mplus 8.0 software was used to construct a structural equation model with ACEs as the independent variable, cognitive function as the dependent variable, and social isolation and functional limitations as mediating variables. In this study, ACEs were positively associated with social isolation and functional limitations (r = 0.081, 0.070, P < 0.01) and negatively associated with cognitive function (r = - 0.132, P < 0.01). Social isolation and functional limitations had chain mediating effects on the relationship between ACEs and cognitive function. ACEs lead to impaired cognitive functioning in middle-aged and older adults, and social isolation and functional limitations influence this relationship. These findings suggest that promoting social integration and physical exercise targeting functional limitations may be important approaches for preventing and mitigating the effects ACEs on cognitive function.
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