SynthesisJournal of thrombosis and thrombolysis2026
The abnormal coagulation status in endometriosis patients: a systematic review and meta-analysis.
Synthesis in Journal of thrombosis and thrombolysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Plasma fibrinogen levels in women with infertility undergoing surgical evaluation for endometriosis: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to comprehensively examine coagulation parameters in patients with endometriosis versus those without to determine hematologic alterations associated with endometriosis.
methodsEmbase, PubMed, CINAHL, Web of Science, the Cochrane Library, CBM, CNKI, VIP, and Wanfang Database were searched through June 2024. The Newcastle-Ottawa Scale was used to evaluate the quality of the studies. Statistical analyses were performed using Stata 16.0 software.
results22 studies with 6,258 participants were included. The results showed significant abnormalities in coagulation parameters in patients with endometriosis compared to those without. Specifically, fibrinogen (FIB) (SMD = 0.57; 95%CI, 0.45 ~ 0.69; P < 0.001), D-dimer (D-D) (SMD = 0.62; 95%CI, 0.27 ~ 0.96; P < 0.001), and platelet count (PLT) (SMD = 0.28; 95%CI, 0.11 ~ 0.45; P = 0.001) were significantly elevated, while activated partial thromboplastin time (APTT) (SMD = -0.13; 95%CI, -0.22~-0.03; P = 0.010), prothrombin time (PT) (SMD = -0.31; 95%CI, -0.54~-0.08; P = 0.009), and thrombin time (TT) (SMD = -0.41; 95%CI, -0.63~-0.20; P < 0.001) were significantly reduced. Moreover, FIB (SMD = 0.47; 95%CI, 0.23 ~ 0.71; P < 0.001), D-D (SMD = 0.38; 95%CI, 0.10 ~ 0.66; P = 0.009), PT (SMD = -0.21; 95%CI, -0.41~-0.02; P = 0.030), and TT (SMD = -0.20; 95%CI, -0.38 ~ 0.01; P = 0.037) also vary between patients with stage I-II and stage III-IV endometriosis.
conclusionMultiple coagulation parameters were abnormal in endometriosis patients, indicating a hypercoagulable state, particularly pronounced in those with stage III-IV endometriosis. Large, globally representative prospective cohorts are needed to elucidate the causal relationship between endometriosis and hypercoagulability.
Indexed as
Identifiers
40745408What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.