Evidence map›Paper›PMID 40745385›Full record

ArticleScientific reports2025

Factors associated with health-related quality of life and financial toxicity among gynecological cancer patients in Southern Nigeria.

Chibuzor F Ogamba, Adedayo Joseph, Ayodeji Kayode Adefemi, Chidike Onyedikachi Ezegwui, Ajay Major, Rasaq Oluwagbemiga Jimoh, Michael Osahumen Orhue, Michael Chudi Ezeanochie, Boniface Uji Ago, Linda Ogochukwu Amah and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chibuzor F OgambaNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK. chibuzor.ogamba@ndph.ox.ac.uk.
Adedayo JosephNSIA-LUTH Cancer Centre, Lagos University Teaching Hospital, Lagos, Nigeria.
Ayodeji Kayode AdefemiDepartment of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria.
Chidike Onyedikachi EzegwuiDepartment of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Enugu State, Nigeria.
Ajay MajorDivision of Haematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Rasaq Oluwagbemiga JimohFaculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
Michael Osahumen OrhueDepartment of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin, Edo State, Nigeria.
Michael Chudi EzeanochieDepartment of Obstetrics and Gynaecology, University of Benin Teaching Hospital, Benin, Edo State, Nigeria.
Boniface Uji AgoDepartment of Obstetrics and Gynaecology, University of Calabar Teaching Hospital, , Cross-Rivers State, Calabar, Nigeria.
Linda Ogochukwu AmahUniversity of Nottingham, Nottingham, UK.
Emeka Emmanuel OkohNnamdi Azikiwe University Teaching Hospital, Awka, Nigeria.
Courage Osamudiamen IdahorNottingham University Hospital, Nottingham, UK.
Mazpa EjikemDepartment of Anaesthesiology, SUNY Downstate Health Sciences University, New York, USA.
Alexander Clive TinworthNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Charilaos ZisouNuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Nwamaka N LasebikanDepartment of Radiation Oncology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Enugu State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The health-related quality of life (HRQoL) and financial toxicity (FT) of women with gynecological cancers in sub-Saharan Africa have not been sufficiently explored. This study assessed predictors of HRQoL and FT, as well as the effect of FT on HRQoL, among affected women in Nigeria. This cross-sectional study investigated 574 women with gynecological cancers receiving care at various stages at five academic hospitals in southern Nigeria between June 2022 and September 2024. HRQoL and FT were evaluated using the FACT-G and FACIT-COST tools, respectively. Multivariable linear regression models estimated the associations of patient characteristics with HRQoL and FT and the effect of FT on HRQoL. Most women experienced FT. After multivariable adjustments, unemployed women, women with ovarian and uterine cancers and choriocarcinoma, higher disease stages, and worse ECOG status had worse HRQoL. Conversely, women in remission had better HRQoL. FT was worse with stages III and IV disease and in those on active treatment. However, older women, those with health insurance, higher income, ovarian cancer and choriocarcinoma had better FT. FT varied linearly with HRQoL, with better HRQoL per unit better FT. This effect was stronger in those with a first tumor, those in pre-treatment and those in remission. Our findings identify possible predictors of HRQoL and FT and suggest potential benefits of reducing FT on the HRQoL of women with gynecological cancers in Nigeria.

Indexed as

Genital Neoplasms, FemaleQuality of LifeAdultAgedCross-Sectional StudiesFemaleHumansMiddle AgedNigeriaFinancial toxicityGynecological cancerNigeriaQuality of life

Identifiers

PMID40745385
PMCPMC12313957

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