Evidence map›Paper›PMID 40745373›Full record

ArticleScientific reports2025

Exploring DNA methylation age and the influence of physical performance, and hypertension on frailty in elderly women.

Pitaksin Chitta, Timothy M Barrow, Busadee Pratumvinit, Atchara Dawangpa, Witchayaporn Kaewboonruang, Saliltip Khamrangsee, Viktor I Korolchuk, Chanachai Sae-Lee

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Pitaksin ChittaResearch Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Timothy M BarrowSchool of Life Sciences, University of Essex, Colchester, UK.
Busadee PratumvinitDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Atchara DawangpaResearch Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Witchayaporn KaewboonruangDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Saliltip KhamrangseeDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Viktor I KorolchukBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Chanachai Sae-LeeResearch Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Chanachai.sae@mahidol.ac.th.

Funding

National Research Council of Thailand N34A660389Siriraj Research Development Fund R016633018
6 · The paper itself

Abstract

Epigenetic age provides a reliable biomarker for biological aging, reflecting the cumulative impact on health over time. Frailty is common among elderly individuals and is further compounded by hypertension, which increases the risk associated with aging. Therefore, we examined the relationship between epigenetic aging and frailty in a non-Western population and explored synergistic effects of frailty and hypertension on epigenetic age. Thai women (60-80 years) were assessed for physical, blood, and biochemical parameters. Age acceleration (AA) residuals were derived to explore deviations between chronological and epigenetic age. We classified 126 participants into robust, pre-frail, and frail groups based on the Fried phenotype and Kihon Checklist. GrimAge1 and GrimAge2 outperformed other epigenetic age estimators in terms of correlation with frailty status. Furthermore, these age models were significantly correlated with physical performance tests. AA varied significantly among groups, with robust individuals having lower Grim1AA and Grim2AA levels than pre-frail individuals. Furthermore, hypertensive participants with pre-frail had significantly different levels of Grim1AA and Grim2AA compared to robust without hypertension. Our findings reveal a complex relationship among frailty, epigenetic age, physical performances, and hypertension. Grim2Age exhibits a strong correlation with chronological age and shows accelerated AA in frail individuals, particularly those with hypertension.

Indexed as

AgingDNA MethylationFrailtyHypertensionPhysical Functional PerformanceAgedAged, 80 and overEpigenesis, GeneticFemaleFrail ElderlyHumansMiddle AgedThailandAge accelerationDNA methylationEpigenetic ageFrailty syndromeHypertension

Identifiers

PMID40745373
PMCPMC12313898

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.