Evidence map›Paper›PMID 40745328›Full record

ReviewJournal of ovarian research2025

Premature ovarian insufficiency restoration after chemotherapy: current achievements and future prospects on its treatment or management.

Hamideh Aboutalebi, Shayan Vafaei, Mohammad Aboutalebi, Hengameh Dortaj, Fatemeh Alipour, Alireza Ebrahimzadeh- Bideskan

Abstract readReview
In one paragraph

Review in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hamideh AboutalebiDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Shayan VafaeiDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad AboutalebiFaculty of Medicine and Surgery, Tor Vergata University, Rome, Italy.
Hengameh DortajDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh AlipourDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza Ebrahimzadeh- BideskanDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. EbrahimzadehBA@mums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the important discussions in assisted reproductive technology (ART) is to maintain fertility in those who are at risk of losing their fertility for various reasons, including cancer and the use of anti-cancer therapies, hence finding a way to maintain fertility during chemotherapy, is vital. Nowadays, in addition to successfully treating patients, oncologists have also focused their attention on preserving their patients' potential of the latter to conceive. Chemotherapy-related ovarian failure, which manifests as a non-physiological form of amenorrhea, can cause dysfunction of the ovary. It is hypothesized that chemotherapeutic agents may cause DNA damage, accelerate follicular apoptosis, oxidative stress, resulting in loss of ovarian reserve function. Hence investigation on utilization of alternatives in order to maintain ovarian function and fertility in cancer survivors seems important. This review provides an update on available and potential future prospects for fertility preservation in women treated with chemotherapy.

Indexed as

Antineoplastic AgentsFertility PreservationPrimary Ovarian InsufficiencyFemaleHumansNeoplasmsOvarian ReserveAntineoplastic AgentsChemotherapyInfertilityOvarian tissueTherapeutics

Identifiers

PMID40745328
PMCPMC12312501

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.