SynthesisWorld journal of surgical oncology2025
Effects of primary tumor location in the basal segment or superior segment (S6) on patient survival in lung cancer: a meta-analysis.
Synthesis in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Prognostic comparison between superior and basal segments in pure-solid non-small cell lung cancer.General thoracic and cardiovascular surgery · 2026Article
- Lymph Node Metastasis and Recurrence Patterns in Clinical Stage IA Lower-Lobe Non-Small Cell Lung Cancer: Toward an Optimal Surgical Strategy for Superior Segment (S6) Tumors.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAmong the key factors influencing the prognosis of lung cancer, the primary tumor site has garnered significant attention in recent years, as it may affect the surgical difficulty and the risk of lymph node metastasis, thereby impacting overall prognosis. Numerous retrospective studies have produced conflicting conclusions, highlighting the necessity for a meta-analysis to consolidate these findings and ascertain the effects of primary tumor location in the basal versus superior segment of the lower lobe(S6) on survival outcomes.
methodsWe conducted a comprehensive literature search up to January 2025 and identified six relevant retrospective studies. We then used the random-effects model in Stata software to perform a meta-analysis to evaluate the impact of the primary tumor location on overall survival(OS) and event-free survival(EFS), EFS was defined as an aggregate of freedom from recurrence (FFR), disease-free survival (DFS), and progression-free survival (RFS).
resultThis study demonstrated that there were no statistically significant differences in OS (S6 vs. Basal segment HR = 1.40, 95% CI: 0.81,2.42 I²=71.8%) and EFS(S6 vs. Basal segment HR = 1.32, 95% CI: 0.69,2.54, I²=76.6%) between patients with the tumor in the S6 segment or basal segment. Begg's test did not find publication bias (p > 0.05). Subgroup analysis indicated that the year of publication, clinical stage, sample size, and both univariate and multivariate analyses did not significantly influence the results.
conclusionThe direct impact of tumor location (S6 vs. Basal segment)on survival is not statistically significant.
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