Evidence map›Paper›PMID 40745263›Full record

ArticleBMC geriatrics2025

Effectiveness and safety of oral nutrition in older patients with moderate dysphagia: a real-world cohort study in geriatric inpatients.

Mohan Li, Shan Jiang, Jiaojiao Li, Xiling Chen, Lan Ma, Qihao Guo, Yuehui Wang, Lan Luo, Liping An, Yonghua Wu and 12 more

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04751032 (Chinese Nutritional Risk Screening and Intervention Registration Study in Geriatric Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04751032 completednot on this map

Chinese Nutritional Risk Screening and Intervention Registration Study in Geriatric Patients

Typeobservational_patient_registrySponsorChinese Medical AssociationRan2020 to 2021Enrolled2,000ConditionsMalnutrition, Old Age
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mohan LiDepartment of Geriatrics at Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Shan JiangDepartment of Geriatrics at Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Jiaojiao LiDepartment of Geriatrics at Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Xiling ChenDepartment of Geriatrics, The Second Affiliated Hospital of Zhengzhou University, No.2 Jingba Road, Jinshui District, Zhengzhou City, Henan Province, 450014, China.
Lan MaDepartment of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, No.246, Xuefu Road, Nangang District, Harbin, Heilongjiang Province, 150086, China.
Qihao GuoDepartment of Geriatrics at Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 600 Yishan road, Shanghai, 200233, China.
Yuehui WangDepartment of Geriatrics, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, Jilin Province, 200233, China.
Lan LuoDepartment of Geriatrics, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong City, 226006, Jiangsu Province, China.
Liping AnDepartment of Geriatrics at Heilongjiang Provincial Hospital, No. 82, Zhongshan Road, Xiangfang District, Harbin, 163000, China.
Yonghua WuDepartment of Geriatrics at Suzhou Municipal Hospital, No. 26 Daoqian Street, Suzhou City, Jiangsu Province, 215002, China.
Wei HuangDepartment of Geriatrics at Tangshan Gongren Hospital, No. 27 Wenhua Road, Lubei District, Tangshan City, Hebei, Heilongjiang Province, 063099, China.
Ludan YuanDepartment of Geriatrics, The First Affiliated Hospital of Jiamusi University, No. 348 Dexiang Street, Xiangyang District, Jiamusi City, Heilongjiang Province, 154003, China.
Lin WangDepartment of Geriatrics at Jiangyin People's Hospital, 163 Shoushan Road, Jiangyin City, Jiangsu Province, 214499, China.
Xiping DingDepartment of Geriatrics, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, No. 17 Lujiang road, Hefei City, Anhui Province, 230001, China.
Xujing ZhaoDepartment of Geriatrics, Peking University Shougang Hospital, No.9, Jinyuanzhuang Road, Shijingshan District, Beijing, 100144, China.
Zhongyuan ZhangDepartment of Geriatrics, Nanjing Tongren Hospital Affiliated to the School of Medicine of Southeast University, No. 2007, Jiyin Avenue, Jiangning District, Nanjing City, Jiangsu Province, 210009, China.
Hongyu ZhangDepartment of Geriatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, Jinan City, Shandong Province, 250012, China.
Yin WuDepartment of Geriatrics at Yingyuan Hospital, Jiading District, No. 420 Shugou Road, Xincheng Road Street, Jiading District, Shanghai, Shanghai, 201822, China.
Rong YangDepartment of Geriatrics at People's Hospital of Shanghai Putuo District, Tongji University, 1291 Jiangning Road, Putuo District, Shanghai, 200060, China.
Yang LiuDepartment of Geriatrics, Tongji Hospital of Tongji University, 389 Xincun Road, Putuo District, Shanghai, 200065, China.
Jian CaoDepartment of Geriatrics, The Second Medical Center, The National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
Xiaohong LiuDepartment of Geriatrics at Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. xhliu41@sina.com.

Funding

Bethune Charitable Foundation X-J-2020-017
6 · The paper itself

Abstract

backgroundDysphagia and malnutrition increase with age and are correlated with adverse clinical outcomes. Researchers have not fully studied the safety and effectiveness between oral nutrition pathway and tube feeding in dysphagic and malnourished elderly individuals.

methodsElderly individuals > 65 years old with nutrition risk admitted to the department of geriatrics from 58 third-grade hospitals between September 2020 and December 2022 were recruited. The analysis was conducted in patients with moderate dysphagia. Baseline characteristics, including demography, nutrition, swallowing function and body function, were collected per inclusion. Nutritional suggestions were given by geriatricians and nutritionists. Nutritional therapy pathways were recorded, and the body and functional measurements were repeated at discharge and the 90-day follow-up. Adverse outcomes, including new-onset pneumonia, falls, unplanned readmission and all-cause death were recorded.

resultsA total of 1027 hospitalized elderly individuals were included, with 168 (16.4%) having moderate dysphagia. Among the participants receiving oral nutrition or tube feeding, 91 (81.3%) and 45 (80.4%) gained sufficient calories after nutritional intervention and were included in the analysis. The median age was 89 (IQR: 82-92) years, 43 (31.6%) were female, and 128 (94.1%) were malnourished. Ninety-one (66.9%) patients were treated with oral nutrition (oral diet or oral nutritional supplements), and 45 (33.1%) were treated with tube feeding. Among the oral nutrition patients, 11 (12.1%), 3 (3.3%), 14 (16.7%) and 2 (2.6%) had new-onset pneumonia, all-cause death, readmission and falls, respectively. The corresponding events in the tube-feeding group were 5 (11.1%), 1 (2.2%), 7 (16.7%) and 1 (2.5%). No statistically significant difference was observed between nutrition treatment pathways. BMI, grip strength and calf circumference increased similarly between the oral nutrition and tube-feeding groups, whereas the percentage of improved MNA-SF status was greater in the oral nutrition group than in the tube-feeding group (53% vs. 26%, p = 0.004).

conclusionsAmong moderately dysphagic geriatric inpatients with malnutrition or nutritional risk, oral nutritional may demonstrate comparable safety to tube feeding regarding new-onset pneumonia, all-cause death, readmissions, and falls during short term follow-up. Oral nutrition may also demonstrate comparable effectiveness in terms of energy supply and improving function, and oral nutrition may be more effective in improving nutritional status.

trial registrationClinicalTrials.gov: NCT04751032.

Indexed as

Deglutition DisordersEnteral NutritionMalnutritionAgedAged, 80 and overCohort StudiesFemaleGeriatric AssessmentHumansInpatientsMaleNutritional StatusDysphagiaMalnutritionNutritional therapyOlder inpatientsTube feeding

Identifiers

PMID40745263
PMCPMC12315445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.