Evidence map›Paper›PMID 40745260›Full record

ArticleScientific reports2025

Isolation, characterization, and biomedical potential of phycoerythrin phycobiliprotein from Kappaphycus alvarezii (Doty) L. M. Liao: antimicrobial, antioxidant, and anticancer activities.

Harinathan Balasundaram, Parthasarathy Seethapathy, Subbiah Sankaralingam, Shunmugiah Mahendran, Murugan Mareeswaran, Jeyaraj Pandiarajan, Pandiaraj Maheswari, Sakthivel Venkatesh, Malaisamy Arunkumar, Girish R Pathade and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Harinathan BalasundaramDepartment of Microbiology, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth, Karad, Maharashtra, 415539, India.ORCID http://orcid.org/0000-0002-9681-8071
Parthasarathy SeethapathyAmrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham, Coimbatore, 642109, India.ORCID http://orcid.org/0000-0003-0660-9311
Subbiah SankaralingamPG and Research Department of Botany, Saraswathi Narayanan College (Autonomous), , Madurai, Tamil Nadu, 625022, India.ORCID http://orcid.org/0000-0002-0916-0591
Shunmugiah MahendranDepartment of Microbiology, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, Tamil Nadu, India. mahi.ran682@gmail.com.ORCID http://orcid.org/0000-0001-5075-3666
Murugan MareeswaranDepartment of Microbiology, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, Tamil Nadu, India.ORCID http://orcid.org/0009-0005-6739-4723
Jeyaraj PandiarajanDepartment of Biotechnology, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, Tamil Nadu, India.ORCID http://orcid.org/0000-0002-6875-3063
Pandiaraj MaheswariDepartment of Microbiology, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi, Tamil Nadu, India.ORCID http://orcid.org/0000-0003-1653-6128
Sakthivel VenkateshPG and Research Department of Botany, Saraswathi Narayanan College (Autonomous), , Madurai, Tamil Nadu, 625022, India.ORCID http://orcid.org/0000-0003-2751-5816
Malaisamy ArunkumarTranscription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, 110067, India.ORCID http://orcid.org/0000-0003-4398-1534
Girish R PathadeDepartment of Microbiology, Krishna Institute of Science and Technology, Krishna Vishwa Vidyapeeth, Karad, Maharashtra, 415539, India.ORCID http://orcid.org/0009-0007-9187-5521
Deepu PanditaGovernment Department of School Education, Jammu, Jammu and Kashmir, 180001, India. deepupandita@gmail.com.ORCID http://orcid.org/0000-0002-8361-1872
Anu PanditaVatsalya Clinic, Krishna Nagar, New Delhi, 110051, India.
Fazal UllahCollege of Life Sciences, Northwest Normal University, Lanzhou, 730070, China.
Hosam O ElansaryDepartment of Plant Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID http://orcid.org/0000-0002-4476-2408
Muhammad NazimState Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, People's Republic of China.
Adel A FickakDepartment of Agricultural Engineering, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID http://orcid.org/0000-0003-2425-9810
Mohamed A RashwanDepartment of Agricultural Engineering, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.ORCID http://orcid.org/0000-0002-5606-958X
Ihab Mohamed MoussaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

Funding

Hosam O. Elansary Researchers Supporting Project number (RSPD2025R741), King Saud University.
6 · The paper itself

Abstract

Kappaphycus alvarezii (Doty) L. M. Liao, a red seaweed widely cultivated for carrageenan polysaccharide, is also a potential source of the valuable pigment phycoerythrin (PE). Therefore, this study aims to extract phycoerythrin from K. alvarezii, evaluate its antimicrobial, antioxidant, and anticancer activities, and identify its biomedical potential for future therapeutic applications. The protein content of phycoerythrin pigment extracted from K. alvarezii was found to be 69.84% and showed excellent antimicrobial activity against Klebsiella oxytoca and Proteus mirabilis, with a minimum inhibition zone of 11 mm. It showed significant in vitro antioxidant activity, as analyzed using total antioxidant, hydrogen peroxide scavenging, reducing power, DPPH, and ABTS assays. Further, the pigment exhibited potent cytotoxicity against a human lung cancer cell line, with an IC

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAntioxidantsPhycobiliproteinsPhycoerythrinRhodophytaAnti-Bacterial AgentsCell Line, TumorCell ProliferationEdible SeaweedsHumansMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsPhycobiliproteinsPhycoerythrinBioactive moleculesLung cancerMolecular dockingPhycoerythrinPigment analysisRed seaweed

Identifiers

PMID40745260
PMCPMC12314021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.