Evidence map›Paper›PMID 40745156›Full record

ArticleNature communications2025

Queuosine is incorporated into precursor tRNA before splicing.

Wei Guo, Igor Kaczmarczyk, Kevin Kopietz, Florian Flegler, Stefano Russo, Ege Cigirgan, Andrzej Chramiec-Głąbik, Łukasz Koziej, Cansu Cirzi, Jirka Peschek and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wei Guo *Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0009-0009-1463-3099
Igor Kaczmarczyk *Małopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.ORCID http://orcid.org/0000-0002-5607-7416
Kevin KopietzInstitute of Pharmaceutical and Biomedical Science (IPBS), Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID http://orcid.org/0009-0007-0423-4049
Florian FleglerInstitut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany.
Stefano RussoFaculty of Biosciences, Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7539-0427
Ege CigirganBiochemistry Center (BZH), Heidelberg University, Heidelberg, Germany.
Andrzej Chramiec-GłąbikMałopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.
Łukasz KoziejMałopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.ORCID http://orcid.org/0000-0003-3885-3845
Cansu CirziDivision of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jirka PeschekBiochemistry Center (BZH), Heidelberg University, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8158-9301
Klaus ReuterInstitut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany.
Mark HelmInstitute of Pharmaceutical and Biomedical Science (IPBS), Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0002-0154-0928
Sebastian GlattMałopolska Centre of Biotechnology, Jagiellonian University, Kraków, Poland.ORCID http://orcid.org/0000-0003-2815-7133
Francesca TuortoCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany. francesca.tuorto@medma.uni-heidelberg.de.ORCID http://orcid.org/0000-0003-1625-1181

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 439669440 TRR319 RMaP TP A06Deutsche Forschungsgemeinschaft (German Research Foundation) 439669440 TRR319 RMaP TP C03Deutsche Forschungsgemeinschaft (German Research Foundation) 442512666Deutsche Forschungsgemeinschaft (German Research Foundation) TU5371-2EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101001394
6 · The paper itself

Abstract

Each newly transcribed tRNA molecule must undergo processing and receive modifications to become functional. Queuosine (Q) is a tRNA modification present at position 34 of four tRNAs with "GUN" anticodons. Among these, the precursor of tRNA

Indexed as

Nucleoside QRNA PrecursorsRNA SplicingRNA, TransferAnimalsAnticodonCaenorhabditis elegansCryoelectron MicroscopyHumansIntronsMicePentosyltransferasesAnticodonNucleoside QPentosyltransferasesRNA PrecursorsRNA, Transfer

Identifiers

PMID40745156
PMCPMC12313893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.