Evidence map›Paper›PMID 40745154›Full record

ArticleNature communications2025

Cryo-EM reveals an extrahelical allosteric binding site at the M

Wessel A C Burger, Jesse I Mobbs, Bhavika Rana, Jinan Wang, Keya Joshi, Patrick R Gentry, Mahmuda Yeasmin, Hariprasad Venugopal, Aaron M Bender, Craig W Lindsley and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Wessel A C Burger *Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.ORCID http://orcid.org/0000-0003-2047-2593
Jesse I Mobbs *Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.ORCID http://orcid.org/0000-0001-6979-1427
Bhavika Rana *Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.
Jinan Wang *Computational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
Keya JoshiComputational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0009-0001-8139-478X
Patrick R GentryDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.
Mahmuda YeasminDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia.
Hariprasad VenugopalRamaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Vic, Australia.ORCID http://orcid.org/0000-0001-5230-2973
Aaron M BenderDepartment of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Craig W LindsleyDepartment of Pharmacology, Warren Center for Neuroscience Drug Discovery and Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Yinglong MiaoComputational Medicine Program and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. Yinglong_Miao@med.unc.edu.ORCID http://orcid.org/0000-0003-3714-1395
Arthur ChristopoulosDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. arthur.christopoulos@monash.edu.ORCID http://orcid.org/0000-0003-4442-3294
Celine ValantDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. celine.valant@monash.edu.ORCID http://orcid.org/0000-0002-2509-7465
David M ThalDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic, Australia. david.thal@monash.edu.ORCID http://orcid.org/0000-0002-0325-2524

Funding

Enhanced Sampling of G-Protein-Coupled Receptor-G Protein InteractionsR01GM132572 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, YINGLONG · 2019 to 2023
$1.5M
Department of Education and Training | Australian Research Council (ARC) DP190102950Department of Health | National Health and Medical Research Council (NHMRC) APP1138448Department of Health | National Health and Medical Research Council (NHMRC) APP1150083NIGMS NIH HHS R01 GM132572U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM132572
6 · The paper itself

Abstract

The M

Indexed as

Cryoelectron MicroscopyReceptors, MuscarinicAcetylcholineAllosteric RegulationAllosteric SiteAnimalsBinding SitesHumansMolecular Dynamics SimulationProtein BindingAcetylcholineReceptors, Muscarinic

Identifiers

PMID40745154
PMCPMC12314052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.