ArticleEuropean radiology2026
Quantitative angiographic markers associated with symptomatic radiation-induced changes in supratentorial brain arteriovenous malformations after radiosurgery.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectivesRadiation-induced changes (RICs) may cause neurological deficits in patients with brain arteriovenous malformations (BAVMs) after radiosurgery. The present study investigated quantitative angiographic markers contributing to symptomatic RICs. MATERIALS AND
methodsA total of 131 patients with supratentorial BAVMs who had not received prior treatment and underwent radiosurgery between 2011 and 2020 were included. Patients completed ≥ 24 months of MRI and clinical follow-up. MRIs and angiograms taken before radiosurgery were analyzed for morphological characteristics and quantitative angiographic parameters. Symptomatic RICs were defined as neurological symptoms attributed to RICs. The vein-artery (VA) ratio was defined as the sum of all draining vein diameters divided by the sum of all supplying artery diameters. The modified cerebral circulation time (mCCT) was defined as the interval between the bolus arrival time of the ipsilateral cavernous internal carotid artery and the parietal vein. Logistic regression models were used to evaluate associations between these markers and symptomatic RICs.
resultsSymptomatic RICs developed in 27 (20.6%) of 131 patients. Nine patients with symptomatic RICs were hospitalized. Multivariable analysis revealed that a lower VA ratio and shorter mCCT were independently associated with symptomatic RICs. Furthermore, the quantitative angiographic model exhibited a higher performance in association with symptomatic RICs than the angioarchitectural model did.
conclusionA lower VA ratio and shorter mCCT were quantitative angiographic markers of venous outflow impairment and high blood flow of BAVMs, respectively. These markers may quantify the hemodynamic effect that contributes to symptomatic RICs development in patients with BAVMs after radiosurgery. KEY POINTS: Question Can quantitative angiographic markers be used to evaluate the risks of symptomatic radiation-induced changes (RICs) in patients with brain arteriovenous malformations (BAVMs) after radiosurgery? Findings BAVMs with a lower vein-artery ratio or shorter modified cerebral circulation time were associated with higher risks of symptomatic RICs development. Clinical relevance Quantification of the BAVM hemodynamic effect that contributes to symptomatic RICs development may help therapeutic decision-making for patients with BAVMs after radiosurgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.