ArticleCommunications chemistry2025
Photo-CIDNP for quantification of micromolar analytes in urine.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Towards target diagnostics of low-concentrated molecules in biofluids, NMR spectroscopy faces limitations due to low sensitivity, signal overlap, and high equipment costs. Hyperpolarization methods such as photo-chemically induced dynamic nuclear polarization (photo-CIDNP) can mitigate some of these challenges. In this study, we explore the potential of steady-state photo-CIDNP to quantify target molecules in urine samples. Matrix interference poses a significant challenge to quantitative measurements, and we thus establish two counteracting methods: spiking and biofluid dilution. Experiments conducted in both high (14.1 T) and low (1.9 T) magnetic fields demonstrate the effectiveness of photo-CIDNP-based quantification at micromolar levels for the analytes sumatriptan and paracetamol. We report limits of quantification (LOQs) in complex matrices down to 3.5 μM and average errors of less than 26% with the spiking method and less than 11% using biofluid dilution. This proof-of-concept study highlights the potential of NMR supported by photo-CIDNP as a target diagnostic tool for rapid drug quantification and clinical monitoring applications, especially with low-cost benchtop NMR devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.