ArticleScientific reports2025
Drug induced liver injury in HIV patients on dolutegravir based antiretroviral therapy regimens in Wolaita Sodo comprehensive specialized hospital.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Age-Related Variations in Clinical and Biochemical Profiles of People Living With HIV.AIDS research and treatment · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug induced liver injury is the most common and life-threatening condition associated with antiretroviral therapy. Dolutegravir (DTG) based combination antiretroviral therapy (ART) is currently first line treatment for HIV infected patients in Ethiopia. However, its effect on liver is not addressed. Therefore, this study aimed to assess the incidence of DTG based ART induced liver injury as first-line HIV treatment among peoples living with HIV. Hospital based retrospective cohort study was conducted in Wolaita Sodo Comprehensive Specialized Hospital ART unit, in South Ethiopia. Data was extracted from patient medical recording card. Non parametric Mann-Whitney U test was used to compare the medians between groups for continuous variables and Fisher's exact test was employed for categorical variables. Univariate and multivariate survival Cox regression was employed to assess predictor variables for drug induced liver injury. The effect of the dolutegravir based regimen on liver enzymes were assessed with paired sample t-test. Kaplan Maier survival analysis was used to estimate mean survival function. A statistical significance was considered at p-value ≤ 0.05. Out of 234 patients on dolutegravir based combination therapy, 68 (29.1%) had drug induced liver injury (DILI). Predictors for DILI were higher baseline alkaline phosphatase (ALP) and experience with other ART. Among DILI cases, 67 (98.5) were associated with cholestatic type of drug induced liver injury. Only 1.5% had both cholestatic and hepatocellular type of DILI. There was significant increment in alanine aminotransferases (ALT), aspartate aminotransferases (AST), and alkaline phosphatase (ALP), body weight and blood glucose level (p < 0.001). However, there is no significant change in creatinine level (p > 0.05). The study demonstrated a significant elevation in liver enzymes, body weight and blood glucose levels in patients taking DTG based combination therapy. The most common drug induced liver injury was cholestatic type. Predictor variables for drug induced liver injury were increased baseline ALP and treatment history with other antiretroviral therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.