SynthesisChinese journal of traumatology = Zhonghua chuang shang za zhi2026
Platelet-rich plasma in anterior cruciate ligament reconstruction: An updated systematic review and quantitative meta-analysis of randomized controlled trials.
Synthesis in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of platelet-rich plasma on clinical outcomes within two years after anterior cruciate ligament reconstruction: a systematic review and meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2025Pooled it
- Orthobiologics in anterior cruciate ligament injuries.Journal of experimental orthopaedics · 2026Review
- Remnant-preserving selective posterolateral bundle reconstruction for partial ACL tears: a retrospective comparative study of functional outcomes, graft maturation, and return-to-sport rates with and without biologic augmentation.BMC musculoskeletal disorders · 2026Article
- Poor Adherence to Minimum Information for Studies Evaluating Biologics in Orthopaedics Guidelines: Platelet-Rich Plasma-Augmented ACL Reconstruction.Orthopaedic journal of sports medicine · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnterior cruciate ligament (ACL) injuries significantly impact athletes' careers and quality of life, necessitating ACL reconstruction to restore knee functionality. Platelet-rich plasma (PRP) has been investigated as an adjunct therapy for enhancing recovery post-ACL reconstruction due to its potential pro-regenerative properties. However, the empirical evidence on PRP's efficacy in ACL reconstruction outcomes remains mixed. This study aims to evaluate the effectiveness and safety of PRP vs. control treatments in patients undergoing ACL reconstruction, focusing on pain management and knee function recovery.
methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a systematic review and meta-analysis of randomized controlled trials comparing PRP with control interventions post-ACL reconstruction. Comprehensive searches were performed across PubMed, Scopus, Web of Science, and Cochrane Library databases up to July 2024. We used "platelet-rich plasma", "controls", and "anterior cruciate ligament reconstruction surgery" as keywords. Statistical analysis was conducted using RevMan 5.3, employing the inverse variance method under a random effects model. We reported outcomes as mean difference (MD) or standardized with confidence intervals (CI). A p < 0.05 was considered statistically significant.
resultsThe analysis incorporated data from 18 studies involving 1082 patients. KT-1000 measurements indicated improved knee stability (MD: -0.57 mm, 95% CI: -0.94 to -0.20, p = 0.002). However, no significant improvements were observed in the Lysholm score (MD: 0.68, 95% CI: =1.24 to 2.26, p = 0.484), visual analog scale pain score (MD: -0.34, 95% CI: -0.68 to -0.01, p = 0.057), International Knee Documentation Committee score (MD: 1.08, 95% CI: -1.05 to 3.42, p = 0.298), Tegner score (MD: 0.13, 95% CI: -0.32 to 0.57, p = 0.575), and femoral and tibial tunnel diameters (femoral MD: -0.07 mm, 95% CI: -0.46 to 0.32, p = 0.726; tibial MD: 0.08 mm, 95% CI: -0.60 to 0.75, p = 0.818).
conclusionOur findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction. However, further high-quality randomized controlled trials are needed to clarify PRP's overall effectiveness and optimal use in ACL reconstruction rehabilitation protocols.
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