Evidence map›Paper›PMID 40744839›Full record

ArticleMicrobiology spectrum2025

Nontuberculous mycobacteria remodel lung microbiota in cystic fibrosis-associated respiratory infections.

Michelle Hardman, Sarah Higgi, Liam Hanson, Kristin Schutz, Matthew J Wargo, Charlotte C Teneback, Thomas W V Daniels, Christopher van der Gast, Damian W Rivett

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle HardmanDepartment of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Sarah HiggiThe Grange University Hospital, Cwmbran, Gwent, United Kingdom.
Liam HansonDepartment of Life Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Kristin SchutzDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Matthew J WargoDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Charlotte C TenebackDivision of Pulmonary and Critic, Care Medicine, Department of Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.
Thomas W V DanielsWessex Adult Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom.
Christopher van der GastDepartment of Applied Sciences, Northumbria University, Newcastle, United Kingdom.ORCID 0000-0003-1101-4048
Damian W RivettDepartment of Natural Sciences, Manchester Metropolitan University, Manchester, United Kingdom.ORCID 0000-0002-1852-6137

Funding

Cystic Fibrosis Trust VIA078Jean Shanks Foundation
6 · The paper itself

Abstract

Nontuberculous mycobacterial (NTM) infections in people with cystic fibrosis (pwCF) can have detrimental effects on prognosis and pose significant challenges to treatment. However, there are still questions regarding the contribution and influence of NTMs on the respiratory microbiome and the mechanisms by which NTMs cause infections. Here, we investigate the impact of NTM infection on microbiome composition and lung function (percent predicted forced expiratory volume in 1 second). Primary comparisons were between culture-positive cohorts for

Indexed as

Cystic FibrosisLungMicrobiotaMycobacterium Infections, NontuberculousNontuberculous MycobacteriaRespiratory Tract InfectionsAdultCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansMaleMycobacterium abscessusPseudomonas aeruginosaYoung AdultCystic Fibrosis Transmembrane Conductance RegulatorBurkholderia cepacia complexCFTR modulator therapycystic fibrosismicrobiomeNontuberculous mycobacteriumPseudomonas aeruginosarespiratory infection

Identifiers

PMID40744839
PMCPMC12403607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.