Evidence map›Paper›PMID 40744729›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.

Seyed Mojtaba Hosseini, Katinka Stecina, Shiva Nemati, Rachel R Wang, Jiasi Vicky Zhang, Soheila Karimi-Abdolrezaee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seyed Mojtaba HosseiniDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada.
Katinka StecinaDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada.ORCID 0000-0001-5341-2613
Shiva NematiDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada.
Rachel R WangDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada.
Jiasi Vicky ZhangDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada.
Soheila Karimi-AbdolrezaeeDepartment of Physiology and Pathophysiology, Spinal Cord Research Centre, Rady Faculty of Health Sciences, University of Manitoba Winnipeg, Winnipeg, Manitoba R3E0J9, Canada Soheila.Karimi@umanitoba.ca.ORCID 0000-0002-0683-2663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive neuronal loss, progressive neurodegeneration, and circuit impairment are the key pathological features of spinal cord injury (SCI). The intrinsic capacity of the injured spinal cord to replenish damaged neurons and reassemble the disrupted spinal circuitry is restricted. Transplantation of exogenous neural precursor cells (NPCs) has shown promise to structurally repair the injured spinal network. However, proper maturation and integration of newly generated neurons from NPC graft within the zhost spinal circuit has remained challenging. Here, in adult female Sprague Dawley rats, we demonstrate that blockade of CSPG/LAR/PTP-σ axis in combination with neuromodulation by activation of 5-HT

Indexed as

Nerve NetNeural Stem CellsSpinal Cord InjuriesAnimalsFemaleRatsRats, Sprague-DawleyRecovery of Function5-HT1/2/7 receptorscircuit reconnectivityCSPGshuman neural precursor cellsneurological recoveryspinal cord injury

Identifiers

PMID40744729
PMCPMC12392074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.