Evidence map›Paper›PMID 40744720›Full record

Observational studyAJNR. American journal of neuroradiology2025

The Brush Sign Is Associated with a More Severe Oxygen Metabolic Impairment of the Ischemic Penumbra: An MRI-Based Study in Patients with Acute Stroke.

Guillaume Criton, Marc Hermier, Charles de Bourguignon, Laura Mechtouff, Delphine Gamondès, Anna Martin, Emilien Jupin-Delevaux, Tae-Hee Cho, Laurent Derex, Paul Clottes and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guillaume CritonFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.ORCID https://orcid.org/0009-0005-6017-3178
Marc HermierFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.ORCID https://orcid.org/0000-0002-4461-2346
Charles de BourguignonClinical Investigation Center (C.d.B.), Bron, France.
Laura MechtouffStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.
Delphine GamondèsFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.
Anna MartinFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.
Emilien Jupin-DelevauxFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.
Tae-Hee ChoStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.ORCID https://orcid.org/0000-0001-8677-2447
Laurent DerexStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.ORCID https://orcid.org/0000-0002-0909-8900
Paul ClottesStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.
Elodie OngStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.
Norbert NighoghossianStroke Department (L.M., T.-H.C., L.D., P.C., E.O., N.N., Y.B.), East Group Hospital, Bron, France.
Yves BerthezeneFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France.ORCID https://orcid.org/0000-0001-6725-7861
Alexandre Bani-SadrFrom the Department of Neuroradiology (G.C., M.H., D.G., A.M., E.J.-D., Y.B., A.B.-S.), East Group Hospital, Bron, France apbanisadr@gmail.com.ORCID https://orcid.org/0000-0002-1808-2484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIn acute stroke, the brush sign has been linked to an increased risk of hemorrhagic transformation. We aimed to assess the oxygen metabolic abnormalities occurring in patients with acute ischemic stroke (AIS) exhibiting the brush sign on admission MRI and its prognostic value at follow-up. MATERIALS AND

methodsWe retrospectively analyzed data from the Cohort of Patients to Identify Biological and Imaging Markers of Cardiovascular Outcomes in Stroke cohort (NCT: 03149705), a single-center observational study that enrolled patients treated with thrombectomy from 2016 to 2022. DSC-MRI was used to generate cerebral metabolic rate of oxygen (CMRO

resultsWe included 204 of 321 (63.6%) participants enrolled in the cohort (114 men, median age 69.0 years and median NIHSS score 14.0). Of these 204 patients, 70 (34.3%) exhibited the brush sign. They had higher baseline NIHSS score (median: 15.5 versus 13.0,

conclusionsThe brush sign on admission MRI was associated with a more severe reduction in CMRO

Indexed as

Ischemic StrokeMagnetic Resonance ImagingOxygenAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesThrombectomyOxygen

Identifiers

PMID40744720
PMCPMC12453504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.