Evidence map›Paper›PMID 40744711›Full record

ArticleRNA (New York, N.Y.)2025

40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.

Hironao Wakabayashi, Mingyi Zhu, Elizabeth J Grayhack, David H Mathews, Dmitri N Ermolenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hironao WakabayashiDepartment of Biochemistry & Biophysics at the School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
Mingyi ZhuDepartment of Biochemistry & Biophysics at the School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
Elizabeth J GrayhackDepartment of Biochemistry & Biophysics at the School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.ORCID 0000-0003-2400-5490
David H MathewsDepartment of Biochemistry & Biophysics at the School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA dmitri_ermolenko@urmc.rochester.edu david_mathews@urmc.rochester.edu.
Dmitri N ErmolenkoDepartment of Biochemistry & Biophysics at the School of Medicine and Dentistry and Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA dmitri_ermolenko@urmc.rochester.edu david_mathews@urmc.rochester.edu.ORCID 0000-0002-7554-5967

Funding

Structural Dynamics of TranslationR35GM141812 · NIGMS · UNIVERSITY OF ROCHESTER · PI ERMOLENKO, DMITRI · 2021 to 2025
$2.8M
RNA Structure Modeling Using Physics and Sequence ComparisonR35GM145283 · NIGMS · UNIVERSITY OF ROCHESTER · PI DAVID H. MATHEWS · 2022 to 2026
$2.7M
Acquisition of a Typhoon FLA 9500 Laser Scanning ImagerS10OD021489 · OD · UNIVERSITY OF ROCHESTER · PI BUTLER, JAMES SCOTT · 2017 to 2017
$130k
NIGMS NIH HHS R35 GM141812NIGMS NIH HHS R35 GM145283NIH HHS S10 OD021489
6 · The paper itself

Abstract

During eukaryotic translation initiation, the small (40S) ribosomal subunit is recruited to the 5' cap and subsequently scans the 5' untranslated region (5' UTR) of mRNA in search of the start codon. The molecular mechanism of mRNA scanning remains unclear, particularly the requirement for and identity of a translocase. Here, using GFP reporters in

Indexed as

Codon, InitiatorRibosome Subunits, Small, EukaryoticRNA, Messenger5' Untranslated RegionsDiffusionMutationPeptide Chain Initiation, TranslationalProtein BiosynthesisSaccharomyces cerevisiaeSaccharomyces cerevisiae Proteins5' Untranslated RegionsCodon, InitiatorRNA, MessengerSaccharomyces cerevisiae ProteinsmRNA scanningone-dimensional diffusionribosometranslation initiation

Identifiers

PMID40744711
PMCPMC12415969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.