ArticleJournal of rhinology : official journal of the Korean Rhinologic Society2025
Phenotypic Analysis of Nasal CD69+ CD4+ Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps.
Article in Journal of rhinology : official journal of the Korean Rhinologic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Tertiary lymphoid structures in chronic rhinosinusitis with nasal polyps: spatial organization, pathological functions, and implications for surgical strategy and biologic therapy.Frontiers in immunology · 2026Review
- Tissue-resident memory T cells in the nasal mucosa: gatekeepers of chronicity and relapse in allergic rhinitis.Frontiers in immunology · 2026Review
- Distinct Profiles of Patient-Reported Outcomes Across Allergen Signatures in Chronic Rhinosinusitis.Life (Basel, Switzerland) · 2025Article
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3 authors.
Funding
Abstract
BACKGROUND AND
objectivesChronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their phenotypic and functional characteristics in the nasal tissue of patients with eosinophilic CRS (ECRS) remain poorly defined.
methodsNasal polyp tissue and/or peripheral blood (PB) samples were obtained from patients with ECRS undergoing endoscopic sinus surgery. The phenotypes and functions of nasal CD69+ CD4+ T cells were analyzed using flow cytometry.
resultsThe frequency of CD69+ CD103- cells among nasal CD4+ T cells was significantly higher in patients with ECRS compared to controls. Analysis of paired PB and nasal tissue samples from ECRS patients revealed that CD69+ CD103- CD4+ T cells were almost exclusively present in nasal tissues and exhibited tissue-resident phenotypes, marked by high expression of CD49a and CXCR6. In ECRS, these nasal CD69+ CD103- CD4+ T cells expressed high levels of T helper 2 (Th2) cell markers, including CRTH2 and GATA3. Consistently, these T cells demonstrated a robust capacity to produce IL-4 and IL-5. These findings were corroborated by analyses of publicly available single-cell RNA sequencing datasets. Furthermore, the frequency of nasal CD69+ CD103- CD4+ T cells was significantly associated with higher Lund-Mackay CT scores and reduced olfactory function in patients with ECRS.
conclusionThe current investigation demonstrates that nasal CD69+ CD103- CD4+ TRM cells include a high frequency of Th2 cells and are associated with severe disease.
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