Evidence map›Paper›PMID 40744483›Full record

ArticleOrthopaedic surgery2025

Establishment of Subtrochanteric Fracture in Pre-Clinical Animal Model.

Poornima Palanisamy, Simon Kwoon-Ho Chow, Shuai Li, Michelle Meng-Chen Li, Wing-Hoi Cheung, Ling Qin, Yong-Ping Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Poornima PalanisamyDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
Simon Kwoon-Ho ChowMusculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Hong Kong Special Administrative Region, The Chinese University of Hong Kong, Hong Kong, SAR, China.ORCID https://orcid.org/0000-0003-1742-980X
Shuai LiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, SAR, China.
Michelle Meng-Chen LiMusculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Hong Kong Special Administrative Region, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Wing-Hoi CheungMusculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Hong Kong Special Administrative Region, The Chinese University of Hong Kong, Hong Kong, SAR, China.
Ling QinMusculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, Hong Kong Special Administrative Region, The Chinese University of Hong Kong, Hong Kong, SAR, China.ORCID https://orcid.org/0000-0001-6173-6167
Yong-Ping ZhengDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, SAR, China.

Funding

Research Grants Council, University Grants Committee of the Hong Kong Special Administrative Region, China AoEM-40220Research Grants Council, University Grants Committee of the Hong Kong Special Administrative Region, China T13-402/17-N
6 · The paper itself

Abstract

objectiveAbout 7%-34% of the femur fracture contributes to subtrochanteric fracture, and only very little research is available about these fractures when compared to common hip fractures. Hence, the aim of this study was to develop a clinically relevant and reproducible open fracture model in rabbits at the subtrochanteric region to understand the fracture healing mechanism at this site and to explore treatment effects of biophysical intervention in future studies.

methodsAn open osteotomy was created in 32 adult New Zealand white rabbits at the subtrochanteric region, followed by customized titanium internal fixations. The internal fixator consists of a 3D printed titanium compression plate with cortical screws for locking. The fracture healing was monitored for 6 weeks, and the corresponding radiography, MicroCT, and histomorphometry analysis were performed at regular intervals.

resultsFour rabbits were excluded due to complications (4/32), including bone dislocation one week post-surgery (3/32). Fracture healing progression was observed in radiographic images. MicroCT analysis showed increased callus volume after 42 days. Histomorphometry revealed remodeled bone area with a higher number of osteocyte cells.

conclusionThe rabbit fracture model of an open femoral osteotomy at the subtrochanteric region has been successfully established, with the facilitation of an internal fixator consisting of a 3D printed titanium compression plate with cortical screws for locking. Applications of this model are being investigated, including different biophysical stimulation methods for accelerating fracture healing.

Indexed as

Disease Models, AnimalFracture Fixation, InternalHip FracturesAnimalsBone PlatesBone ScrewsFracture HealingOsteotomyPrinting, Three-DimensionalRabbitsX-Ray Microtomographybone repairfracture healingosteotomyrabbit modelsubtrochanteric fracture

Identifiers

PMID40744483
PMCPMC12404857

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.