Evidence map›Paper›PMID 40744402›Full record

ArticleAntiviral research2025

Discovery of broad-spectrum antivirals targeting viral proteases using in silico structural modeling and cellular analysis.

Dharmeshkumar Patel, Ramyani De, Niloufar Azadi, Sujin Lee, Savannah Shooter, Sarah Amichai, Shaoman Zhou, Danielle Monroe, Cameron Mahanke, Tamara R McBrayer and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dharmeshkumar PatelCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Ramyani DeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Niloufar AzadiCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Sujin LeeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Savannah ShooterCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Sarah AmichaiCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Shaoman ZhouCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Danielle MonroeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Cameron MahankeCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Tamara R McBrayerCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Michael MuczynskiDepartment of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Abdullah Al-HomoudiDepartment of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Joseph EngelDepartment of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Yury A BochkovDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
James E GernDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Ladislau C KovariDepartment of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, 48201, USA.
Franck AmblardCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA.
Raymond F SchinaziCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, GA, 30322, USA. Electronic address: rschina@emory.edu.

Funding

Mechanisms of Enhanced Neutralizing Antibody Responses to Rhinovirus CR01AI148707 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BOCHKOV, YURY A · 2020 to 2024
$3.9M
Broad-spectrum therapeutics against SARS-CoV-2 3CL proteaseR01AI161570 · NIAID · EMORY UNIVERSITY · PI FITZPATRICK, ELIZABETH ANN, KOVARI, LADISLAU CHRISTOPHER · 2021 to 2025
$3.3M
Anti-norovirus protease inhibitors for immunocompromised patientsR01AI173229 · NIAID · EMORY UNIVERSITY · PI KOVARI, LADISLAU CHRISTOPHER, SCHINAZI, RAYMOND FELIX · 2023 to 2025
$3.1M
NIAID NIH HHS R01 AI148707NIAID NIH HHS R01 AI161570NIAID NIH HHS R01 AI173229
6 · The paper itself

Abstract

The development of broad-spectrum antivirals is a high-priority goal to prevent future global outbreaks. Some antiviral agents developed for specific viral protein targets may exhibit broad-spectrum antiviral activity or provide helpful information for broad-spectrum drug development. In this study, we compared the sequence- and structure-based similarity of SARS-CoV-2 3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesSARS-CoV-2Viral Protease InhibitorsViral ProteasesCatalytic DomainComputer SimulationCOVID-19 Drug TreatmentDrug DiscoveryEnterovirusHumansMolecular Docking SimulationNorovirusRhinovirusAntiviral AgentsCoronavirus 3C ProteasesViral Protease InhibitorsViral Proteases

Identifiers

PMID40744402
PMCPMC12366546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.