ArticleJournal of theoretical biology2025
Linking within-host immune dynamics to between-host transmission and reinfection risk.
Article in Journal of theoretical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
The link between the virus and antibody dynamics of an infected host to the transmission of the virus to a susceptible population remains a central problem in science as it involves several complex and dynamic processes at different scales. In this study, we integrate deterministic and stochastic within-host models to explore multiscale transmission dynamics. Our methodology accounts for encounter frequency, within-host variability, and reinfection dynamics to assess their impact on epidemic progression. Our results show that within-host stochasticity disrupts synchronized viral peaks, leading to a more uniform transmission pattern and reducing the effectiveness of interventions targeting peak viral load. Considering the half-life of antibodies is 25 days, cycles of reinfections cannot be maintained in small populations, but reinfections become self-sustaining when a circular network exceeds 21 nodes, allowing indefinite circulation. These findings emphasize the need for integrating within-host dynamics in epidemic research.
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