Evidence map›Paper›PMID 40744000›Full record

Trial reportNeonatology2025

Neurobehavioral Outcomes at 10 Years of Age following Delayed Umbilical Cord Clamping: A Follow-Up Study after a Randomized Trial.

Manuela Isacson, Lena Hellström-Westas, Magnus Domellöf, Jovanna Dahlgren, Josefine Roswall, Ola Andersson

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neonatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manuela IsacsonDepartment of Clinical Sciences Lund, Pediatrics, Lund University, Lund, Sweden.
Lena Hellström-WestasDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Magnus DomellöfDepartment of Clinical Sciences, Pediatrics Umeå University, Umeå, Sweden.
Jovanna DahlgrenDepartment of Pediatrics, Göteborg Pediatric Growth Research Center (GP-GRC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Josefine RoswallDepartment of Pediatrics, Göteborg Pediatric Growth Research Center (GP-GRC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Ola AnderssonDepartment of Clinical Sciences Lund, Pediatrics, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Introduction: The aim of this study was to explore long-term behavioral consequences of early versus delayed cord clamping (CC) in school-aged children. The hypothesis was that early CC would be associated with an increased risk of symptoms associated with attention deficit hyperactivity disorder (ADHD) due to the lower iron stores following early CC compared with delayed CC.

methodsExploratory, long-term follow-up study of a randomized controlled trial in Sweden. Full-term, vaginally born, neonates to healthy mothers were originally included and randomized to either early (≤10 s) or delayed (≥180 s) CC. At 10 years of age, scores from the screening questionnaire Swanson, Nolan and Pelham Scale IV (SNAP-IV), that identifies symptoms suggestive of ADHD (but do not diagnose ADHD), were compared between groups of early and delayed CC.

resultsWe assessed 139/382 (36.4%) children, 64 early CC and 75 delayed CC. No significance in total score and subgroup scores of SNAP-IV was seen when comparing early and delayed CC. In the primary outcome, total scores, mean (standard deviation) of early CC was 14.64 (13.94) and for delayed CC 13.59 (13.41), p = 0.65.

conclusionTiming of umbilical CC and iron status were not associated with symptoms associated with ADHD in 10-year-old children. Studies with higher follow-up rates and in populations with high prevalence of iron deficiency are needed to verify or discard the findings. Understanding if delayed CC has long-lasting neurobehavioral or neurodevelopmental effects can help develop guidelines and program about neonatal care. </p>.

Indexed as

Attention Deficit Disorder with HyperactivityUmbilical CordUmbilical Cord ClampingChildFemaleFollow-Up StudiesHumansInfant, NewbornMaleSwedenTime FactorsDelayed cord clampingIron deficiencyNeurodevelopment

Identifiers

PMID40744000
PMCPMC12503560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.