Evidence map›Paper›PMID 40743437›Full record

ArticleEmerging microbes & infections2025

Three-dimensional mapping of tick-borne encephalitis virus distribution in the mouse brain using a newly engineered TurboGFP reporter virus.

Michaela Berankova, Simone Leoni, Jiri Holoubek, Jan Haviernik, Jiri Salat, Denis Grandgirard, Stephen L Leib, Daniel Ruzek

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michaela BerankovaDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Simone LeoniInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Jiri HoloubekDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Jan HaviernikLaboratory of Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic.
Jiri SalatDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Denis GrandgirardInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Stephen L LeibInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Daniel RuzekDepartment of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) is a neurotropic orthoflavivirus that invades the central nervous system, leading to severe neurological manifestations. In this study, we developed a reporter virus comprising TurboGFP-expressing TBEV (tGFP-TBEV) as a versatile tool for advancing TBEV research. The tGFP-TBEV facilitates quantitative measurement of viral replication, enables precise tracking of individual infected cells, and supports high-throughput screening of potential antiviral compounds and virus-neutralization assays. Furthermore, tGFP-TBEV proved effective as a model for studying TBEV infection in rat organotypic cerebellar slices cultured

Indexed as

BrainEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneAnimalsGenes, ReporterHumansImaging, Three-DimensionalLuminescent ProteinsMiceMice, Inbred C57BLRatsViral TropismVirus ReplicationLuminescent Proteinslight-sheet microscopyneurotropismorganotypic cerebellar slicesreporter virusesTBEVtissue clearing

Identifiers

PMID40743437
PMCPMC12442459

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.