Evidence map›Paper›PMID 40743392›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment.

Kevin Rose, Eric Herrmann, Eve Kakudji, Javier Lizarrondo, A Yasemin Celebi, Florian Wilfling, Samantha C Lewis, James H Hurley

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A planar dimer of bovine ATP synthase.Cell death and differentiation · 2026
    Article
  5. The Human Autophagy Core Complexes.Annual review of biochemistry · 2026
    Review
  6. Article
  7. Article
  8. Diel remodeling and cellular integration of the nitroplast.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. A perspective on the future of heart failure research.Journal of molecular and cellular cardiology plus · 2026
    Article
  12. Molecular mechanisms of mitochondrial AAA+ proteases.The Journal of biological chemistry · 2026
    Review
  13. Article
  14. Subtomogram Averaging of Membrane Complexes in Organelle-Derived Vesicles.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  15. Mitochondrial pearling: membrane biophysics, CaFrontiers in cell and developmental biology · 2026
    Review
  16. Article
  17. Cryo-EM structure of the prohibitin complex in open conformation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

8 authors.

Kevin RoseAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0002-9373-4147
Eric HerrmannAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0003-0499-0083
Eve KakudjiAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0009-0007-1179-5901
Javier LizarrondoAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0001-5199-4170
A Yasemin CelebiCalifornia Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA 94720.
Florian WilflingAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0002-6559-7261
Samantha C LewisAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0001-6306-443X
James H HurleyAligning Science Across Parkinson's Collaborative Research Network, Chevy Chase, MD 20815.ORCID 0000-0001-5054-5445

Funding

The Midwest Center for Cryo-Electron TomographyU24GM139168 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WRIGHT, ELIZABETH R · 2020 to 2025
$41.7M
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC) SupplementU24GM139166 · NIGMS · STANFORD UNIVERSITY · PI Wah Chiu · 2020 to 2026
$11.7M
Systems analysis of mitochondrial genome maintenance in physiological contextR35GM147218 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Samantha C Lewis · 2022 to 2026
$2.1M
Aligning Science Across Parkinson's (ASAP) ASAP-000350NIGMS NIH HHS R35 GM147218NIGMS NIH HHS U24 GM139166NIGMS NIH HHS U24 GM139168
6 · The paper itself

Abstract

Defective mitochondrial quality control in response to loss of mitochondrial membrane polarization is implicated in Parkinson's disease by mutations in

Indexed as

MitochondriaMitophagyAntimycin ACell Line, TumorCryoelectron MicroscopyElectron Microscope TomographyHumansMitochondrial MembranesOligomycinsProhibitinsUbiquitin-Protein LigasesAntimycin AOligomycinsparkin proteinPHB protein, humanProhibitinsUbiquitin-Protein Ligasesautophagycryo-ETmitochondriamitophagyprohibitin

Identifiers

PMID40743392
PMCPMC12337332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.