Evidence map›Paper›PMID 40743352›Full record

ArticleScience (New York, N.Y.)2025

Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution.

Steven J Cook, Cristine A Kalinski, Curtis M Loer, Nadin Memar, Maryam Majeed, Sarah Rebecca Stephen, Daniel J Bumbarger, Metta Riebesell, Barbara Conradt, Ralf Schnabel and 2 more

Abstract readComparative Study
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Uncovering Sex Differences in thebioRxiv : the preprint server for biology · 2026
    Article
  2. RAEM: random-access electron microscopy for revisitable 3D imaging.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Evolution of sensory systems underlies the emergence of predatory feeding behaviors in nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. From nematode to Nobel: How community-shared resources fueled the rise ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Identity and functions of monoaminergic neurons in the predatory nematodebioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Steven J CookDepartment of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.ORCID 0000-0002-1345-7566
Cristine A KalinskiDepartment of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.ORCID 0000-0001-6227-5403
Curtis M LoerDepartment of Biology, University of San Diego, San Diego, CA, USA.
Nadin MemarInstitut für Genetik, Technische Universität Braunschweig, Braunschweig, Germany.
Maryam MajeedDepartment of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.ORCID 0000-0003-4018-0766
Sarah Rebecca StephenDepartment of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.ORCID 0009-0001-6746-2731
Daniel J BumbargerMax Planck Institute for Biology Tübingen, Department for Evolutionary Biology, Tübingen, Germany.ORCID 0000-0001-6224-1633
Metta RiebesellMax Planck Institute for Biology Tübingen, Department for Evolutionary Biology, Tübingen, Germany.
Barbara ConradtFaculty of Biology, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.ORCID 0000-0002-3731-4308
Ralf SchnabelInstitut für Genetik, Technische Universität Braunschweig, Braunschweig, Germany.
Ralf J SommerMax Planck Institute for Biology Tübingen, Department for Evolutionary Biology, Tübingen, Germany.ORCID 0000-0003-1503-7749
Oliver HobertDepartment of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.ORCID 0000-0002-7634-2854

Funding

Genetic analyses of complete circuit formation in Caenorhabditis elegansF32MH115438 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COOK, STEVEN JAY · 2017 to 2021
$226k
Howard Hughes Medical InstituteNIMH NIH HHS F32 MH115438
6 · The paper itself

Abstract

Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micrographic reconstruction of the brain of the predatory nematode

Indexed as

Behavior, AnimalBiological EvolutionBrainCaenorhabditis elegansConnectomeRhabditidaAnimalsCell DeathFeeding BehaviorNeuronsPredatory BehaviorSynapses

Identifiers

PMID40743352
PMCPMC12330220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.