Evidence map›Paper›PMID 40742904›Full record

ArticleACS applied materials & interfaces2025

STING Agonist-Loaded Physalis Mottle Virus-like Particles as a Potent Prophylactic for Metastatic Melanoma.

Andrea Simms, Jessica Fernanda Affonso de Oliveira, Nicole F Steinmetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrea SimmsAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.ORCID 0000-0002-3104-0588
Jessica Fernanda Affonso de OliveiraAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.ORCID 0000-0002-5474-2355
Nicole F SteinmetzAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, California 92093, United States.ORCID 0000-0002-0130-0481

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jing Yang · 1985 to 2026
$124.9M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Dual-pronged nano-drug delivery using plant virus-like particles.R01CA224605 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nicole Franziska Steinmetz · 2017 to 2026
$4.0M
Bioprinting Plant Virus Nanoparticles for Immunotherapy and Relapse Prevention of Ovarian CancerR01CA253615 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, FIERING, STEVEN · 2020 to 2024
$3.1M
Toward translation of a plant virus-based in situ vaccination nanotechnologyR01CA274640 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIERING, STEVEN, RANJAN, ASHISH · 2022 to 2025
$2.5M
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
Acquisition of a High Resolution TOF Mass SpectrometerS10RR025636 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MOLINSKI, TADEUSZ F · 2010 to 2010
$305k
NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA224605NCI NIH HHS R01 CA253615NCI NIH HHS R01 CA274640NCRR NIH HHS S10 RR025636NIGMS NIH HHS P41 GM103311NIH HHS S10 OD023527
6 · The paper itself

Abstract

Stimulator of interferon genes (STING) agonists have been presented as a compelling cancer therapeutic for many years yet have been unable to break past clinical trials. To date, the best use cases for STING agonists are as intratumoral therapeutics for solid tumors, but in human trials, rapid wash-out and low efficacy hamper success. Systemic administrations of STING agonists have also been explored, but hurdles include enzymatic instability, leading to rapid clearance and immune toxicity. To overcome these challenges, nanoparticle delivery technologies have been proposed, and in the present study, we bioconjugated a STING agonist to the internal cavity of Physalis mottle virus (PhMV)-like nanoparticles (termed PhMV-STG). PhMV-STG demonstrated enhanced and extended interferon activity

Indexed as

Antineoplastic AgentsLung NeoplasmsMelanomaMembrane ProteinsNanoparticlesPhysalisAnimalsCell Line, TumorHumansMiceSTING ProteinAntineoplastic AgentsMembrane ProteinsSTING1 protein, humanSTING Proteincancer immunotherapycancer prophylaxismelanomametastatic cancerPhysalis mottle virus (PhMV)stimulator of interferon genes (STING)virus-like particles (VLPs)

Identifiers

PMID40742904
PMCPMC12863269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.